Modulation of osteoclast formation

Julian M.W. Quinn, Matthew T. Gillespie

Research output: Contribution to journalReview ArticleResearchpeer-review

89 Citations (Scopus)


Osteoclasts are derived following the fusion of precursors of hematopoietic and myelomonocytic origin after appropriate stimulus, such as that afforded by RANKL and M-CSF. Thus the osteoclast can be considered as a specialized type of macrophage, and several of the factors that affect osteoclast formation also have affects upon macrophage differentiation. Inhibitors of osteoclast formation may perturb RANKL or M-CSF signalling or affect other signalling pathways. Several of these inhibitors are discussed with the view of their capacity to influence osteoclast differentiation, but not necessarily their activity.

Original languageEnglish
Pages (from-to)739-745
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - 18 Mar 2005
Externally publishedYes

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