Modulation of interferon gamma response through orally administered bovine colostrum in active adolescent boys

Mahenderan Appukutty, Ammu Kutty Radhakrishnan, Kalavathy Ramasamy, Abu Bakar Abdul Majeed, Mohd Ismail Noor, Nik Shanita Safii, Karuthan Chinna, Poh Bee Koon

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2 Citations (Scopus)


Bovine colostrum (BC) is a rich source of bioactive com-ponents reported to have health promoting effects. The purpose of the present study was to determine the effects of six-week supplementation of BC on the production of gamma-interferon (IFN-γ) by mitogen-stimulated periph-eral blood leucocytes (PBL) in active adolescent male. Subjects were recruited from the students who were un-der-going regular athletics training. The subjects were randomly assigned into control and experimental groups. The control group (n=18) received daily supplementation of skim milk while the experimental group (n=18) re-ceived bovine colostrum (20 g/day). Fasting venous blood samples were collected on day-0 and day-42 for measurement of IFN-γ produced by concanavalin A (Con A)-stimulated PBL. Interferon-γ levels were quantified using ELISA. Changes in IFN-γ levels from baseline to endpoints for both groups were compared and presented as mean (± SD). Although baseline levels of cytokine concentrations were similar in both groups, there was a decreasing trend in IFN-γ production by the mitogen-stimulated PBL from subjects who received the bovine colostrum supplement compared to controls. The find-ings of the present study suggest that oral supplementa-tion of bovine colostrum for a period of 6 weeks may modulate in vitro IFN-γ concentration.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalBiomedical Research
Issue number1
Publication statusPublished - 2011
Externally publishedYes


  • Adolescent male
  • Bovine colostrum
  • Dietary intervention
  • Immune response

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