Modulation of brain resting-state networks by sad mood induction

Ben J Harrison, Jesus M Pujol, Hector Ortiz, Alexander Fornito, Christos Pantelis, Murat Yucel

Research output: Contribution to journalArticleResearchpeer-review

156 Citations (Scopus)

Abstract

Background: There is growing interest in the nature of slow variations of the blood oxygen level-dependent (BOLD) signal observed in functional MRI resting-state studies. In humans. these slow BOLD variations are thought to reflect an underlying or intrinsic form of brain functional connectivity in discrete neuroanatomical systems. While these resting-state networks maybe relatively enduring phenomena, other evidence suggest that dynamic changes in their functional connectivity may also emerge depending on the brain state subjects during scanning. Methodology/Principle Findings: In this study, we examined healthy subjects (n-24) with a mood induction paradigm during two continuous fMRI recording to assess the effects of a change in self-generated mood state (neutral to sad) on the networks that were common to both experimental states, each showing dominant signal fluctuation in the very low frequency domain ( 0.04 Hz). Between the two states, we observed apparent increases and decreases in the overall functional connectivity of these networks. Primary findings included increased connectivity strength of a paralimbic networks involving the dorsal anterior cingulate and anterior insula cortices with sunjects increasing sadness and decreased functional connectivity of the default mode network. Conclusions/Significance: These findings support recent studies that suggest the functional connectivity of certain resting-state networks may in part, reflect a dynamic image of the current brain state. In our study, this was linked to changes in subjective mood
Original languageEnglish
Article numbere1794
Number of pages12
JournalPLoS ONE
Volume3
Issue number3
DOIs
Publication statusPublished - 2008
Externally publishedYes

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