Modulating T Cell Responses via Autophagy: The Intrinsic Influence Controlling the Function of Both Antigen-Presenting Cells and T Cells

Seth D. Merkley, Cameron J. Chock, Xuexian O. Yang, James Harris, Eliseo F. Castillo

Research output: Contribution to journalReview ArticleResearchpeer-review

41 Citations (Scopus)


Autophagy is a homeostatic and inducible process affecting multiple aspects of the immune system. This intrinsic cellular process is involved in MHC-antigen (Ag) presentation, inflammatory signaling, cytokine regulation, and cellular metabolism. In the context of T cell responses, autophagy has an influential hand in dictating responses to self and non-self by controlling extrinsic factors (e.g., MHC-Ag, cytokine production) in antigen-presenting cells (APC) and intrinsic factors (e.g., cell signaling, survival, cytokine production, and metabolism) in T cells. These attributes make autophagy an attractive therapeutic target to modulate T cell responses. In this review, we examine the impact autophagy has on T cell responses by modulating multiple aspects of APC function; the importance of autophagy in the activation, differentiation and homeostasis of T cells; and discuss how the modulation of autophagy could influence T cell responses.

Original languageEnglish
Article number2914
Number of pages19
JournalFrontiers in Immunology
Publication statusPublished - 1 Jan 2018


  • autophagy
  • immunometabolism
  • immunotherapy
  • inflammation
  • macrophages
  • T cells

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