Modified β-turns in breast carcinoma-associated MUC1 related peptides

M. J. Scanlon, M. R. Price, S. J B Tendler

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Abstract

The solution structure of two carcinoma-associated MUC1 core related peptides has been investigated by nuclear magnetic resonance (n.m.r.) spectroscopy. The peptide APDTRPAPG resembles previously studied MUC1 related peptides with a type I β-turn identified in the region PDTR. This portion of the peptide has previously been identified as the binding site for the monoclonal antibodies HMFG-1 and HMFG-2. The peptide where the D has been replaced by its homologue E, which is selectively recognized by the antibody HMFG-1 but not HMFG-2, appears to have a modified turn region. While amide to amide through space connections are observed the results suggest a more open turn structure.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalInternational journal of oncology
Volume2
Issue number2
Publication statusPublished - 1 Jan 1993
Externally publishedYes

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