The solution structure of two carcinoma-associated MUC1 core related peptides has been investigated by nuclear magnetic resonance (n.m.r.) spectroscopy. The peptide APDTRPAPG resembles previously studied MUC1 related peptides with a type I β-turn identified in the region PDTR. This portion of the peptide has previously been identified as the binding site for the monoclonal antibodies HMFG-1 and HMFG-2. The peptide where the D has been replaced by its homologue E, which is selectively recognized by the antibody HMFG-1 but not HMFG-2, appears to have a modified turn region. While amide to amide through space connections are observed the results suggest a more open turn structure.
|Number of pages||3|
|Journal||International Journal of Oncology|
|Publication status||Published - 1 Jan 1993|