TY - JOUR
T1 - Modification of arthropod vector competence via symbiotic bacteria
AU - Beard, C
AU - O'Neill, Scott Leslie
AU - Tesh, R
AU - Richards, F
AU - Aksoy, Serap
PY - 1993
Y1 - 1993
N2 - Some of the world s most devastating diseases are transmitted by arthropod vectors. Attempts to control these arthropods are currently being challenged by the widespread appearance of insecticide resistance. It is therefore desirable to develop alternative strategies to complement existing methods of vector control. In this review, Charles Beard, Scott O Neill, Robert Tesh, Frank Richards and Serap Aksoy present an approach for introducing foreign genes into insects in order to confer refractoriness to vector populations, ie. the inability to transmit disease-causing agents. This approach aims to express foreign anti-parasitic or anti-viral gene products in symbiotic bacteria harbored by insects. The potential use of naturally occurring symbiont-based mechanisms in the spread of such refractory phenotypes is also discussed.
AB - Some of the world s most devastating diseases are transmitted by arthropod vectors. Attempts to control these arthropods are currently being challenged by the widespread appearance of insecticide resistance. It is therefore desirable to develop alternative strategies to complement existing methods of vector control. In this review, Charles Beard, Scott O Neill, Robert Tesh, Frank Richards and Serap Aksoy present an approach for introducing foreign genes into insects in order to confer refractoriness to vector populations, ie. the inability to transmit disease-causing agents. This approach aims to express foreign anti-parasitic or anti-viral gene products in symbiotic bacteria harbored by insects. The potential use of naturally occurring symbiont-based mechanisms in the spread of such refractory phenotypes is also discussed.
UR - http://ac.els-cdn.com/0169475893901423/1-s2.0-0169475893901423-main.pdf?_tid=70a35942e3e30905ef3dfdc45183dc5e&acdnat=1336353854_5dd46dab67c8b988f7d744
U2 - 10.1016/0169-4758(93)90142-3
DO - 10.1016/0169-4758(93)90142-3
M3 - Letter
SN - 0169-4758
VL - 9
SP - 179
EP - 183
JO - Parasitology Today
JF - Parasitology Today
IS - 5
ER -