Modern Intermittent Haemodialysis (IHD) is an Effective Method of Removing Salicylate in Chronic Topical Salicylate Toxicity

Anselm Wong, Kathy Mac, Anders Aneman, Jeffrey Wong, Betty S. Chan

Research output: Contribution to journalArticleOtherpeer-review

4 Citations (Scopus)


Introduction: There are limited data on modern intermittent hemodialysis (IHD) efficacy on salicylate elimination from topical poisoning. Case report: A 54-year-old male sought treatment for dyspnea but was then diagnosed with salicylate toxicity from topical application of Dencorub Extra Strength Heat Gel® for 1 week. Each tube contained 100 g with 26 % methylsalicylate (26 g). Laboratory workup was remarkable for an elevated anion gap of 30 and salicylate concentration of 78.7 mg/dL [5.7 mmol/L (N <0.4 mmol/L)]. Treatment with urinary alkalinization was followed by hemodialysis for 5 h. Extraction ratios were 0.44 with clearance rates of 78.5 mL/min. Salicylate concentrations fell rapidly following initiation of hemodialysis with no rebound observed. Discussion: Modern high flux IHD is an effective method of removing salicylates in the treatment of chronic topical poisoning.

Original languageEnglish
Pages (from-to)130-133
Number of pages4
JournalJournal of Medical Toxicology
Issue number1
Publication statusPublished - 1 Mar 2016
Externally publishedYes


  • Hemodialysis
  • Poisoning
  • Salicylate
  • Topical

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