Models of insulin signalling and longevity

M. D W Piper; Colin Selman; Joshua J. McElwee; Linda Partridge

doi:10.1016/j.ddmod.2005.11.001

Models of insulin signalling and longevity

M. D W Piper, Colin Selman, Joshua J. McElwee, Linda Partridge

Research output: Contribution to journal › Review Article › Research › peer-review

9 Citations (Scopus)

Abstract

Single gene mutations that extend lifespan have drastically changed ageing research because they offer potential answers to the questions of why and how we age. Mutations that lower activity of the insulin and insulin-like growth factor signalling (IIS) pathways extend the lifespan of worms, flies and mice. It is possible, therefore, to learn about human ageing from the conserved features of these long-lived models. Here, we summarise the available data in this light.

Original language	English
Pages (from-to)	249-256
Number of pages	8
Journal	Drug Discovery Today: Disease Models
Volume	2
Issue number	4
DOIs	https://doi.org/10.1016/j.ddmod.2005.11.001
Publication status	Published - 2005
Externally published	Yes

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10.1016/j.ddmod.2005.11.001

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abstract = "Single gene mutations that extend lifespan have drastically changed ageing research because they offer potential answers to the questions of why and how we age. Mutations that lower activity of the insulin and insulin-like growth factor signalling (IIS) pathways extend the lifespan of worms, flies and mice. It is possible, therefore, to learn about human ageing from the conserved features of these long-lived models. Here, we summarise the available data in this light.",

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AB - Single gene mutations that extend lifespan have drastically changed ageing research because they offer potential answers to the questions of why and how we age. Mutations that lower activity of the insulin and insulin-like growth factor signalling (IIS) pathways extend the lifespan of worms, flies and mice. It is possible, therefore, to learn about human ageing from the conserved features of these long-lived models. Here, we summarise the available data in this light.

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Models of insulin signalling and longevity

Abstract

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