Models of insulin signalling and longevity

M. D W Piper, Colin Selman, Joshua J. McElwee, Linda Partridge

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)


Single gene mutations that extend lifespan have drastically changed ageing research because they offer potential answers to the questions of why and how we age. Mutations that lower activity of the insulin and insulin-like growth factor signalling (IIS) pathways extend the lifespan of worms, flies and mice. It is possible, therefore, to learn about human ageing from the conserved features of these long-lived models. Here, we summarise the available data in this light.

Original languageEnglish
Pages (from-to)249-256
Number of pages8
JournalDrug Discovery Today: Disease Models
Issue number4
Publication statusPublished - 2005
Externally publishedYes

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