Modelling traumatic brain injury and posttraumatic epilepsy in rodents

Rhys D. Brady, Pablo M. Casillas-Espinosa, Denes V. Agoston, Edward H. Bertram, Alaa Kamnaksh, Bridgette D. Semple, Sandy R. Shultz

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Posttraumatic epilepsy (PTE) is one of the most debilitating and understudied consequences of traumatic brain injury (TBI). It is challenging to study the effects, underlying pathophysiology, biomarkers, and treatment of TBI and PTE purely in human patients for a number of reasons. Rodent models can complement human PTE studies as they allow for the rigorous investigation into the causal relationship between TBI and PTE, the pathophysiological mechanisms of PTE, the validation and implementation of PTE biomarkers, and the assessment of PTE treatments, in a tightly controlled, time- and cost-efficient manner in experimental subjects known to be experiencing epileptogenic processes. This article will review several common rodent models of TBI and/or PTE, including their use in previous studies and discuss their relative strengths, limitations, and avenues for future research to advance our understanding and treatment of PTE.

Original languageEnglish
Pages (from-to)8-19
Number of pages12
JournalNeurobiology of Disease
Volume123
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • Posttraumatic epilepsy
  • Review
  • Translational research
  • Traumatic brain injury

Cite this

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abstract = "Posttraumatic epilepsy (PTE) is one of the most debilitating and understudied consequences of traumatic brain injury (TBI). It is challenging to study the effects, underlying pathophysiology, biomarkers, and treatment of TBI and PTE purely in human patients for a number of reasons. Rodent models can complement human PTE studies as they allow for the rigorous investigation into the causal relationship between TBI and PTE, the pathophysiological mechanisms of PTE, the validation and implementation of PTE biomarkers, and the assessment of PTE treatments, in a tightly controlled, time- and cost-efficient manner in experimental subjects known to be experiencing epileptogenic processes. This article will review several common rodent models of TBI and/or PTE, including their use in previous studies and discuss their relative strengths, limitations, and avenues for future research to advance our understanding and treatment of PTE.",
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Modelling traumatic brain injury and posttraumatic epilepsy in rodents. / Brady, Rhys D.; Casillas-Espinosa, Pablo M.; Agoston, Denes V.; Bertram, Edward H.; Kamnaksh, Alaa; Semple, Bridgette D.; Shultz, Sandy R.

In: Neurobiology of Disease, Vol. 123, 01.03.2018, p. 8-19.

Research output: Contribution to journalReview ArticleResearchpeer-review

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