TY - JOUR
T1 - Modelling the multiple anatomical site transmission of Mycoplasma genitalium among men who have sex with men in Australia
AU - Xu, Xianglong
AU - Bradshaw, Catriona S.
AU - Chow, Eric P.F.
AU - Ong, Jason J.
AU - Hocking, Jane S.
AU - Fairley, Christopher K.
AU - Zhang, Lei
N1 - Funding Information:
This work was supported by Australian National Health and Medical Research Council Emerging Leadership Investigator Grant (Grant GNT1173361 to C.S.B, Grant GNT1172873 to EPFC, and Grant GNT1172900 to C.F.K); and Australian National Health and Medical Research Council early career fellowship (Grant APP1104781 to J.J.O); and National Natural Science Foundation of China (Grant 81950410639 to L. Z), Outstanding Young Scholars Funding (Grant 3111500001 to L. Z); and Xi’an Jiaotong University Basic Research and Profession Grant (Grant xtr022019003 to L. Z, Grant xzy032020032 to L. Z); and Epidemiology modelling and risk assessment (Grant 20200344 to L. Z); and Xi’an Jiaotong University Young Talent Support Grant (Grant YX6J004 to L. Z). The funders had no role in study design, data collection and analysis, decision to publish, or manuscript preparation. We thank Mark Chung at the Melbourne Sexual Health Centre for his assistance in preparing Fig. 3.
Publisher Copyright:
© 2021, The Author(s).
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/12
Y1 - 2021/12
N2 - Mycoplasma genitalium (M. genitalium) is a recently recognised and important sexually transmitted infection among men who have sex with men (MSM). The role of oral sex, rimming, and kissing on M. genitalium transmission in MSM is unclear. We created four deterministic susceptible-infectious-susceptible epidemic models to examine the role that different sexual behaviours play in transmitting M. genitalium at the oropharynx, urethra anorectum among men who have sex with men in Australia. Our results suggest that oral and anal sex without other sexual practices (model 1) replicate well single site infection at the oropharynx, urethra and anorectum and also multi-site infection. If kissing or rimming are added to model 1 (i.e., model 2–4) no substantial improvements in the calibration of the models occur. Model 1 estimates that 3.4% of infections occur at the oropharynx, 34.8% at the urethra and 61.8% at the anorectum. Model 1 also estimates that the proportion of incident M. genitalium transmitted by anal sex was 82.4%, and by oral sex was about 17.6%. Our findings could provide an enhanced understanding of M. genitalium transmission in MSM, thus providing insights into what sexual practices contribute most to transmission.
AB - Mycoplasma genitalium (M. genitalium) is a recently recognised and important sexually transmitted infection among men who have sex with men (MSM). The role of oral sex, rimming, and kissing on M. genitalium transmission in MSM is unclear. We created four deterministic susceptible-infectious-susceptible epidemic models to examine the role that different sexual behaviours play in transmitting M. genitalium at the oropharynx, urethra anorectum among men who have sex with men in Australia. Our results suggest that oral and anal sex without other sexual practices (model 1) replicate well single site infection at the oropharynx, urethra and anorectum and also multi-site infection. If kissing or rimming are added to model 1 (i.e., model 2–4) no substantial improvements in the calibration of the models occur. Model 1 estimates that 3.4% of infections occur at the oropharynx, 34.8% at the urethra and 61.8% at the anorectum. Model 1 also estimates that the proportion of incident M. genitalium transmitted by anal sex was 82.4%, and by oral sex was about 17.6%. Our findings could provide an enhanced understanding of M. genitalium transmission in MSM, thus providing insights into what sexual practices contribute most to transmission.
UR - http://www.scopus.com/inward/record.url?scp=85106939789&partnerID=8YFLogxK
U2 - 10.1038/s41598-021-90627-3
DO - 10.1038/s41598-021-90627-3
M3 - Article
C2 - 34045569
AN - SCOPUS:85106939789
SN - 2045-2322
VL - 11
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 11087
ER -