Modelling the evolution of cerebral aneurysms: biomechanics, mechanobiology and multiscale modelling

Alisa Selimovic; Yiannis Ventikos; Paul N. Watton

doi:10.1016/j.piutam.2014.01.034

Modelling the evolution of cerebral aneurysms: biomechanics, mechanobiology and multiscale modelling

Alisa Selimovic, Yiannis Ventikos, Paul N. Watton

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

16 Citations (Scopus)

Abstract

Intracranial aneurysms (IAs) are abnormal dilatations of the cerebral vasculature. Computational modelling may shed light on the aetiology of the disease and lead to improved criteria to assist diagnostic decisions. We briefly review models of aneurysm evolution to date and present a novel fluid-solid-growth (FSG) framework for patient-specific modelling of IA evolution. We illustrate its application to 4 clinical cases depicting an IA. The section of arterial geometry containing the IA is removed and replaced with a cylindrical section: this represents an idealised section of healthy artery upon which IA evolution is simulated. The utilisation of patient-specific geometries enables G&R to be explicitly linked to physiologically realistic spatial distributions and magnitudes of haemodynamic stimuli. In this study, we investigate the hypothesis that elastin degradation is driven by locally low wall shear stress (WSS). In 3 out of 4 cases, the evolved model IA geometry is qualitatively similar to the corresponding in vivo IA geometry. This suggests some tentative support for the hypothesis that low WSS plays a role in the mechanobiology of IA evolution.

Original language	English
Title of host publication	Proceedings of the 23rd International Congress of Theoretical and Applied Mechanics, ICTAM2012
Publisher	Elsevier
Pages	396-409
Number of pages	14
Volume	10
DOIs	https://doi.org/10.1016/j.piutam.2014.01.034
Publication status	Published - 2014
Externally published	Yes
Event	International Congress of Theoretical and Applied Mechanics 2012 - Beijing, China Duration: 19 Aug 2012 → 24 Aug 2012 Conference number: 23rd http://www.ictam2012.org/

Conference

Conference	International Congress of Theoretical and Applied Mechanics 2012
Abbreviated title	ICTAM 2012
Country/Territory	China
City	Beijing
Period	19/08/12 → 24/08/12
Other	The Proceedings, entitled “Mechanics for the World” and edited by Y. Bai, J. Wang and D. Fang, have been published by Procedia IUTAM, 2014.
Internet address	http://www.ictam2012.org/

Keywords

Evolution
Fluid-solid-growth
Growth
Intracranial aneurysm
Multi-scale modelling
Remodelling
Wall shear stress

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10.1016/j.piutam.2014.01.034

Cite this

@inproceedings{a53db720f1e840cbaf97e62a3dc6daa4,

title = "Modelling the evolution of cerebral aneurysms: biomechanics, mechanobiology and multiscale modelling",

abstract = "Intracranial aneurysms (IAs) are abnormal dilatations of the cerebral vasculature. Computational modelling may shed light on the aetiology of the disease and lead to improved criteria to assist diagnostic decisions. We briefly review models of aneurysm evolution to date and present a novel fluid-solid-growth (FSG) framework for patient-specific modelling of IA evolution. We illustrate its application to 4 clinical cases depicting an IA. The section of arterial geometry containing the IA is removed and replaced with a cylindrical section: this represents an idealised section of healthy artery upon which IA evolution is simulated. The utilisation of patient-specific geometries enables G&R to be explicitly linked to physiologically realistic spatial distributions and magnitudes of haemodynamic stimuli. In this study, we investigate the hypothesis that elastin degradation is driven by locally low wall shear stress (WSS). In 3 out of 4 cases, the evolved model IA geometry is qualitatively similar to the corresponding in vivo IA geometry. This suggests some tentative support for the hypothesis that low WSS plays a role in the mechanobiology of IA evolution.",

keywords = "Evolution, Fluid-solid-growth, Growth, Intracranial aneurysm, Multi-scale modelling, Remodelling, Wall shear stress",

author = "Alisa Selimovic and Yiannis Ventikos and Watton, {Paul N.}",

note = "Funding Information: Alisa Selimovic is a doctoral student funded by the Robert Menzies Memorial Trust. Paul Watton is a University Research Lecturer in the Institute of Biomedical Engineering and is funded by The Centre of Excellence in Personalized Healthcare (funded by the Wellcome Trust and EPSRC, WT 088877/Z/09/Z). This support is gratefully acknowledged.; International Congress of Theoretical and Applied Mechanics 2012, ICTAM 2012 ; Conference date: 19-08-2012 Through 24-08-2012",

year = "2014",

doi = "10.1016/j.piutam.2014.01.034",

language = "English",

volume = "10",

pages = "396--409",

booktitle = "Proceedings of the 23rd International Congress of Theoretical and Applied Mechanics, ICTAM2012",

publisher = "Elsevier",

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url = "http://www.ictam2012.org/",

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Selimovic, A, Ventikos, Y & Watton, PN 2014, Modelling the evolution of cerebral aneurysms: biomechanics, mechanobiology and multiscale modelling. in Proceedings of the 23rd International Congress of Theoretical and Applied Mechanics, ICTAM2012. vol. 10, Elsevier, pp. 396-409, International Congress of Theoretical and Applied Mechanics 2012, Beijing, China, 19/08/12. https://doi.org/10.1016/j.piutam.2014.01.034

Modelling the evolution of cerebral aneurysms: biomechanics, mechanobiology and multiscale modelling. / Selimovic, Alisa; Ventikos, Yiannis; Watton, Paul N.
Proceedings of the 23rd International Congress of Theoretical and Applied Mechanics, ICTAM2012. Vol. 10 Elsevier, 2014. p. 396-409.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

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T1 - Modelling the evolution of cerebral aneurysms

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AU - Ventikos, Yiannis

AU - Watton, Paul N.

N1 - Conference code: 23rd

PY - 2014

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N2 - Intracranial aneurysms (IAs) are abnormal dilatations of the cerebral vasculature. Computational modelling may shed light on the aetiology of the disease and lead to improved criteria to assist diagnostic decisions. We briefly review models of aneurysm evolution to date and present a novel fluid-solid-growth (FSG) framework for patient-specific modelling of IA evolution. We illustrate its application to 4 clinical cases depicting an IA. The section of arterial geometry containing the IA is removed and replaced with a cylindrical section: this represents an idealised section of healthy artery upon which IA evolution is simulated. The utilisation of patient-specific geometries enables G&R to be explicitly linked to physiologically realistic spatial distributions and magnitudes of haemodynamic stimuli. In this study, we investigate the hypothesis that elastin degradation is driven by locally low wall shear stress (WSS). In 3 out of 4 cases, the evolved model IA geometry is qualitatively similar to the corresponding in vivo IA geometry. This suggests some tentative support for the hypothesis that low WSS plays a role in the mechanobiology of IA evolution.

AB - Intracranial aneurysms (IAs) are abnormal dilatations of the cerebral vasculature. Computational modelling may shed light on the aetiology of the disease and lead to improved criteria to assist diagnostic decisions. We briefly review models of aneurysm evolution to date and present a novel fluid-solid-growth (FSG) framework for patient-specific modelling of IA evolution. We illustrate its application to 4 clinical cases depicting an IA. The section of arterial geometry containing the IA is removed and replaced with a cylindrical section: this represents an idealised section of healthy artery upon which IA evolution is simulated. The utilisation of patient-specific geometries enables G&R to be explicitly linked to physiologically realistic spatial distributions and magnitudes of haemodynamic stimuli. In this study, we investigate the hypothesis that elastin degradation is driven by locally low wall shear stress (WSS). In 3 out of 4 cases, the evolved model IA geometry is qualitatively similar to the corresponding in vivo IA geometry. This suggests some tentative support for the hypothesis that low WSS plays a role in the mechanobiology of IA evolution.

KW - Evolution

KW - Fluid-solid-growth

KW - Growth

KW - Intracranial aneurysm

KW - Multi-scale modelling

KW - Remodelling

KW - Wall shear stress

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BT - Proceedings of the 23rd International Congress of Theoretical and Applied Mechanics, ICTAM2012

PB - Elsevier

Y2 - 19 August 2012 through 24 August 2012

ER -

Modelling the evolution of cerebral aneurysms: biomechanics, mechanobiology and multiscale modelling

Abstract

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Keywords

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