Abstract
We have developed a new mathematical model of single cell rabbit sinoatrial node pacemaker activity, employing Markov state kinetic descriptions of ionic currents. Parameters of the model have been adjusted to match experimental recordings of free running action potentials from the periphery of the node, recorded both in the absence and presence of E-4031 - a selective blocker of the rapid delayed rectifier K+ current (iK,r). Results from the model suggest that the effects of E-4031 on action potential waveshape can be reproduced by simply lowering the membrane conductance of iK,r.
| Original language | English |
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| Title of host publication | Second Joint EMBS-BMES Conference 2002, Vols 1-3, Conference Proceedings: Bioengineering - Integrative Methodologies, New Technologies |
| Pages | 1345-1346 |
| Number of pages | 2 |
| Publication status | Published - 2002 |
| Externally published | Yes |
| Event | International Conference of the IEEE Engineering in Medicine and Biology Society 2002 - Houston, United States of America Duration: 23 Oct 2002 → 26 Oct 2002 Conference number: 24th |
Conference
| Conference | International Conference of the IEEE Engineering in Medicine and Biology Society 2002 |
|---|---|
| Abbreviated title | EMBC 2002 |
| Country | United States of America |
| City | Houston |
| Period | 23/10/02 → 26/10/02 |
Cite this
Dokos, S., Boyett, MR., Cloherty, SL., & Lovell, NH. (2002). Modelling pharmacological block of rapid delayed rectifier current by E-4031 in sinoatrial pacemaker cells. In Second Joint EMBS-BMES Conference 2002, Vols 1-3, Conference Proceedings: Bioengineering - Integrative Methodologies, New Technologies (pp. 1345-1346)