Modelling pharmacological block of rapid delayed rectifier current by E-4031 in sinoatrial pacemaker cells

S Dokos, MR Boyett, SL Cloherty, NH Lovell

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

Abstract

We have developed a new mathematical model of single cell rabbit sinoatrial node pacemaker activity, employing Markov state kinetic descriptions of ionic currents. Parameters of the model have been adjusted to match experimental recordings of free running action potentials from the periphery of the node, recorded both in the absence and presence of E-4031 - a selective blocker of the rapid delayed rectifier K+ current (iK,r). Results from the model suggest that the effects of E-4031 on action potential waveshape can be reproduced by simply lowering the membrane conductance of iK,r.
Original languageEnglish
Title of host publicationSecond Joint EMBS-BMES Conference 2002, Vols 1-3, Conference Proceedings: Bioengineering - Integrative Methodologies, New Technologies
Pages1345-1346
Number of pages2
Publication statusPublished - 2002
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2002 - Houston, United States of America
Duration: 23 Oct 200226 Oct 2002
Conference number: 24th

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2002
Abbreviated titleEMBC 2002
CountryUnited States of America
CityHouston
Period23/10/0226/10/02

Cite this

Dokos, S., Boyett, MR., Cloherty, SL., & Lovell, NH. (2002). Modelling pharmacological block of rapid delayed rectifier current by E-4031 in sinoatrial pacemaker cells. In Second Joint EMBS-BMES Conference 2002, Vols 1-3, Conference Proceedings: Bioengineering - Integrative Methodologies, New Technologies (pp. 1345-1346)