Modeling the outcome of structural disconnection on resting-state functional connectivity

Joana Cabral, Etienne Hugues, Morten L. Kringelbach, Gustavo Deco

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)


A growing body of experimental evidence suggests that functional connectivity at rest is shaped by the underlying anatomical structure. Furthermore, the organizational properties of resting-state functional networks are thought to serve as the basis for an optimal cognitive integration. A disconnection at the structural level, as occurring in some brain diseases, would then lead to functional and presumably cognitive impairments.In this work, we propose a computational model to investigate the role of a structural disconnection (encompassing putative local/global and axonal/synaptic mechanisms) on the organizational properties of emergent functional networks. The brain's spontaneous neural activity and the corresponding hemodynamic response were simulated using a large-scale network model, consisting of local neural populations coupled through white matter fibers. For a certain coupling strength, simulations reproduced healthy resting-state functional connectivity with graph properties in the range of the ones reported experimentally. When the structural connectivity is decreased, either globally or locally, the resultant simulated functional connectivity exhibited a network reorganization characterized by an increase in hierarchy, efficiency and robustness, a decrease in small-worldness and clustering and a narrower degree distribution, in the same way as recently reported for schizophrenia patients. Theoretical results indicate that most disconnection-related neuropathologies should induce the same qualitative changes in resting-state brain activity.

Original languageEnglish
Pages (from-to)1342-1353
Number of pages12
Issue number3
Publication statusPublished - Sep 2012
Externally publishedYes


  • Computational model
  • Disconnection
  • Functional network
  • Graph-theory
  • Schizophrenia
  • Small-world
  • Structural connectivity

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