Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device

Miguel E Combariza; Xinghuo Yu; Francisco Tovar-Lopezy; Warwick Scott Nesbitt; Arnan Mitchell

doi:10.1109/BRC.2013.6487538

Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device

Miguel E Combariza, Xinghuo Yu, Francisco Tovar-Lopezy, Warwick Scott Nesbitt, Arnan Mitchell

Australian Centre for Blood Diseases

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

1 Citation (Scopus)

Abstract

Cardiovascular diseases remain the main cause of death worldwide despite decades of intensive research. Understanding the role that hemodynamics play in dynamic platelet aggregation is fundamental to the development of new antithrombotic treatments able to minimise associated morbidity rates. In this paper we explore the dynamics of platelet aggregation in response to shear rate micro-gradients in vitro in a microfluidics device, and formulate dynamical linear models using system identification techniques. The proposed models provide insight into the mechanistic variables regulating platelet aggregation and warrant further work in the dynamic exploration of platelet mechanotransduction. ? 2013 IEEE

Original language	English
Title of host publication	Proceedings of the Biosignals and Biorobotics Conference (BRC), 2013 ISSNIP
Editors	Fran Zappulla, Gerry Grenier, Kenneth Moore, Susan Hassler
Place of Publication	USA
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	286 - 290
Number of pages	5
Volume	2013
ISBN (Print)	9781467330244
DOIs	https://doi.org/10.1109/BRC.2013.6487538
Publication status	Published - 2013
Event	ISSNIP-IEEE Biosignals and Biorobotics Conference - Biosignals and Robotics for Better and Safer Living (BRC) 2013 - University Fedral Rio Janerio, Rio Janerio, Brazil Duration: 18 Feb 2013 → 20 Feb 2013 https://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=21337 http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=6482466 (IEEE Conference proceedings)

Conference

Conference	ISSNIP-IEEE Biosignals and Biorobotics Conference - Biosignals and Robotics for Better and Safer Living (BRC) 2013
Abbreviated title	BRC 2013
Country/Territory	Brazil
City	Rio Janerio
Period	18/02/13 → 20/02/13
Internet address	https://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=21337 http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=6482466 (IEEE Conference proceedings)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1109/BRC.2013.6487538

Cite this

Combariza, M. E., Yu, X., Tovar-Lopezy, F., Nesbitt, W. S., & Mitchell, A. (2013). Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device. In F. Zappulla, G. Grenier, K. Moore, & S. Hassler (Eds.), Proceedings of the Biosignals and Biorobotics Conference (BRC), 2013 ISSNIP (Vol. 2013, pp. 286 - 290). IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/BRC.2013.6487538

Combariza, Miguel E ; Yu, Xinghuo ; Tovar-Lopezy, Francisco et al. / Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device. Proceedings of the Biosignals and Biorobotics Conference (BRC), 2013 ISSNIP. editor / Fran Zappulla ; Gerry Grenier ; Kenneth Moore ; Susan Hassler. Vol. 2013 USA : IEEE, Institute of Electrical and Electronics Engineers, 2013. pp. 286 - 290

@inproceedings{80a3d3136c72444eafd40f86f3a89e5e,

title = "Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device",

abstract = "Cardiovascular diseases remain the main cause of death worldwide despite decades of intensive research. Understanding the role that hemodynamics play in dynamic platelet aggregation is fundamental to the development of new antithrombotic treatments able to minimise associated morbidity rates. In this paper we explore the dynamics of platelet aggregation in response to shear rate micro-gradients in vitro in a microfluidics device, and formulate dynamical linear models using system identification techniques. The proposed models provide insight into the mechanistic variables regulating platelet aggregation and warrant further work in the dynamic exploration of platelet mechanotransduction. ? 2013 IEEE",

author = "Combariza, {Miguel E} and Xinghuo Yu and Francisco Tovar-Lopezy and Nesbitt, {Warwick Scott} and Arnan Mitchell",

year = "2013",

doi = "10.1109/BRC.2013.6487538",

language = "English",

isbn = "9781467330244",

volume = "2013",

pages = "286 -- 290",

editor = "Fran Zappulla and Gerry Grenier and Kenneth Moore and Susan Hassler",

booktitle = "Proceedings of the Biosignals and Biorobotics Conference (BRC), 2013 ISSNIP",

publisher = "IEEE, Institute of Electrical and Electronics Engineers",

address = "United States of America",

note = "ISSNIP-IEEE Biosignals and Biorobotics Conference - Biosignals and Robotics for Better and Safer Living (BRC) 2013, BRC 2013 ; Conference date: 18-02-2013 Through 20-02-2013",

url = "https://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=21337, http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=6482466",

}

Combariza, ME, Yu, X, Tovar-Lopezy, F, Nesbitt, WS & Mitchell, A 2013, Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device. in F Zappulla, G Grenier, K Moore & S Hassler (eds), Proceedings of the Biosignals and Biorobotics Conference (BRC), 2013 ISSNIP. vol. 2013, IEEE, Institute of Electrical and Electronics Engineers, USA, pp. 286 - 290, ISSNIP-IEEE Biosignals and Biorobotics Conference - Biosignals and Robotics for Better and Safer Living (BRC) 2013, Rio Janerio, Brazil, 18/02/13. https://doi.org/10.1109/BRC.2013.6487538

Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device. / Combariza, Miguel E; Yu, Xinghuo; Tovar-Lopezy, Francisco et al.
Proceedings of the Biosignals and Biorobotics Conference (BRC), 2013 ISSNIP. ed. / Fran Zappulla; Gerry Grenier; Kenneth Moore; Susan Hassler. Vol. 2013 USA: IEEE, Institute of Electrical and Electronics Engineers, 2013. p. 286 - 290.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

TY - GEN

T1 - Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device

AU - Combariza, Miguel E

AU - Yu, Xinghuo

AU - Tovar-Lopezy, Francisco

AU - Nesbitt, Warwick Scott

AU - Mitchell, Arnan

PY - 2013

Y1 - 2013

N2 - Cardiovascular diseases remain the main cause of death worldwide despite decades of intensive research. Understanding the role that hemodynamics play in dynamic platelet aggregation is fundamental to the development of new antithrombotic treatments able to minimise associated morbidity rates. In this paper we explore the dynamics of platelet aggregation in response to shear rate micro-gradients in vitro in a microfluidics device, and formulate dynamical linear models using system identification techniques. The proposed models provide insight into the mechanistic variables regulating platelet aggregation and warrant further work in the dynamic exploration of platelet mechanotransduction. ? 2013 IEEE

AB - Cardiovascular diseases remain the main cause of death worldwide despite decades of intensive research. Understanding the role that hemodynamics play in dynamic platelet aggregation is fundamental to the development of new antithrombotic treatments able to minimise associated morbidity rates. In this paper we explore the dynamics of platelet aggregation in response to shear rate micro-gradients in vitro in a microfluidics device, and formulate dynamical linear models using system identification techniques. The proposed models provide insight into the mechanistic variables regulating platelet aggregation and warrant further work in the dynamic exploration of platelet mechanotransduction. ? 2013 IEEE

UR - http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=6487538

U2 - 10.1109/BRC.2013.6487538

DO - 10.1109/BRC.2013.6487538

M3 - Conference Paper

SN - 9781467330244

VL - 2013

SP - 286

EP - 290

BT - Proceedings of the Biosignals and Biorobotics Conference (BRC), 2013 ISSNIP

A2 - Zappulla, Fran

A2 - Grenier, Gerry

A2 - Moore, Kenneth

A2 - Hassler, Susan

PB - IEEE, Institute of Electrical and Electronics Engineers

CY - USA

T2 - ISSNIP-IEEE Biosignals and Biorobotics Conference - Biosignals and Robotics for Better and Safer Living (BRC) 2013

Y2 - 18 February 2013 through 20 February 2013

ER -

Combariza ME, Yu X, Tovar-Lopezy F, Nesbitt WS, Mitchell A. Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device. In Zappulla F, Grenier G, Moore K, Hassler S, editors, Proceedings of the Biosignals and Biorobotics Conference (BRC), 2013 ISSNIP. Vol. 2013. USA: IEEE, Institute of Electrical and Electronics Engineers. 2013. p. 286 - 290 doi: 10.1109/BRC.2013.6487538

Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device

Abstract

Conference

UN SDGs

Access to Document

Other files and links

Cite this