Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device

Miguel E Combariza, Xinghuo Yu, Francisco Tovar-Lopezy, Warwick Scott Nesbitt, Arnan Mitchell

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

1 Citation (Scopus)

Abstract

Cardiovascular diseases remain the main cause of death worldwide despite decades of intensive research. Understanding the role that hemodynamics play in dynamic platelet aggregation is fundamental to the development of new antithrombotic treatments able to minimise associated morbidity rates. In this paper we explore the dynamics of platelet aggregation in response to shear rate micro-gradients in vitro in a microfluidics device, and formulate dynamical linear models using system identification techniques. The proposed models provide insight into the mechanistic variables regulating platelet aggregation and warrant further work in the dynamic exploration of platelet mechanotransduction. ? 2013 IEEE
Original languageEnglish
Title of host publicationProceedings of the Biosignals and Biorobotics Conference (BRC), 2013 ISSNIP
EditorsFran Zappulla, Gerry Grenier, Kenneth Moore, Susan Hassler
Place of PublicationUSA
PublisherIEEE, Institute of Electrical and Electronics Engineers
Pages286 - 290
Number of pages5
Volume2013
ISBN (Print)9781467330244
DOIs
Publication statusPublished - 2013
EventISSNIP-IEEE Biosignals and Biorobotics Conference - Biosignals and Robotics for Better and Safer Living (BRC) 2013 - University Fedral Rio Janerio, Rio Janerio, Brazil
Duration: 18 Feb 201320 Feb 2013
https://www.ieee.org/conferences_events/conferences/conferencedetails/index.html?Conf_ID=21337
http://ieeexplore.ieee.org/xpl/mostRecentIssue.jsp?punumber=6482466 (IEEE Conference proceedings)

Conference

ConferenceISSNIP-IEEE Biosignals and Biorobotics Conference - Biosignals and Robotics for Better and Safer Living (BRC) 2013
Abbreviated titleBRC 2013
CountryBrazil
CityRio Janerio
Period18/02/1320/02/13
Internet address

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