Modeling biological activities of nanoparticles

Chandana Epa, Frank Robert Burden, Carlos Tassa, Ralph Weissleder, Stanley Shaw, David Alan Winkler

Research output: Contribution to journalArticleResearchpeer-review

126 Citations (Scopus)

Abstract

Products are increasingly incorporating nanomaterials, but we have a poor understanding of their adverse effects. To assess risk, regulatory authorities need more experimental testing of nanoparticles. Computational models play a complementary role in allowing rapid prediction of potential toxicities of new and modified nanomaterials. We generated quantitative, predictive models of cellular uptake and apoptosis induced by nanoparticles for several cell types. We illustrate the potential of computational methods to make a contribution to nanosafety.
Original languageEnglish
Pages (from-to)5808 - 5812
Number of pages5
JournalNano Letters
Volume12
Issue number11
DOIs
Publication statusPublished - 2012

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