Model iterative airway pressure reconstruction during mechanical ventilation asynchrony: shapes and sizes of reconstruction

Chee Pin Tan, Yeong Shiong Chiew, J. Geoffrey Chase, Yeong Woei Chiew, Christopher Pretty, Thomas Desaive, Azrina Md Ralib, Mohd Basri Mat

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther


Model-based methods estimating patient-specific respiratory mechanics may help intensive care clinicians in setting optimal ventilation parameters. However, these methods rely heavily on the quality of measured airway pressure and flow profiles for reliable respiratory mechanics estimation. Thus, asynchronous and/or spontaneous breathing cycles that do not follow a typical passive airway profile affect the performance and reliability of model-based methods. In this study, a model iterative airway pressure reconstruction method is presented. It aims to reconstruct a measured airway pressure affected by asynchronous breathing iteratively, trying to match the profile of passive breaths with no asynchrony or spontaneous breathing effort. Thus, reducing the variability of identified respiratory mechanics over short time periods where changes would be due only to asynchrony or spontaneous artefacts. A total of 2000 breathing cycles from mechanically ventilated patients with known asynchronous breathing were analyzed. It was found that this method is capable of reconstructing an airway pressure free from asynchronous or spontaneous breathing effort. This work focuses on several cases, detailing how iterative pressure reconstruction method performs under different cases, as well as its limitation.

Original languageEnglish
Title of host publication2nd International Conference for Innovation in Biomedical Engineering and Life Sciences - ICIBEL 2017 in conjunction with APCMBE 2017
EditorsJuliana Usman, Fatimah Ibrahim, Mohd Yazed Ahmad, Swe Jyan Teh, Norhamizan Hamzah
Number of pages7
ISBN (Print)9789811075537
Publication statusPublished - 2018
EventInternational Conference for Innovation in Biomedical Engineering and Life Sciences 2017 - Penang, Malaysia
Duration: 10 Dec 201713 Dec 2017
Conference number: 2nd (Proceedings)

Publication series

NameIFMBE Proceedings
ISSN (Print)1680-0737


ConferenceInternational Conference for Innovation in Biomedical Engineering and Life Sciences 2017
Abbreviated titleICIBEL 2017
Internet address


  • Airway pressure reconstruction
  • Asynchrony
  • Mechanical ventilation
  • Spontaneous breathing

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