Abstract
Modelling the respiratory mechanics of mechanically ventilated (MV) patients can provide useful information to guide MV therapy. Two model-based methods were evaluated based on data from three experimental acute respiratory distress syndrome (ARDS) induced piglets and validated against values available from ventilators. A single compartment lung model with integral-based parameter identification was found to be effective in capturing fundamental respiratory mechanics during inspiration. The trends matched clinical expectation and provided better resolution than clinically derived linear model metrics. An expiration time constant model also captured the same trend in respiratory elastance. However, the assumption of constant resistance and a slightly higher fitting error results in less insight than the single compartment model. Further research is required to confirm its application in titrating to optimal MV settings.
Original language | English |
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Title of host publication | 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 |
Pages | 5224-5227 |
Number of pages | 4 |
DOIs | |
Publication status | Published - 2013 |
Externally published | Yes |
Event | International Conference of the IEEE Engineering in Medicine and Biology Society 2013 - Osaka International Convention Center, Osaka, Japan Duration: 3 Jul 2013 → 7 Jul 2013 Conference number: 35th https://ieeexplore.ieee.org/xpl/conhome/6596169/proceeding (Proceedings) |
Publication series
Name | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
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ISSN (Print) | 1557-170X |
Conference
Conference | International Conference of the IEEE Engineering in Medicine and Biology Society 2013 |
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Abbreviated title | EMBC 2013 |
Country/Territory | Japan |
City | Osaka |
Period | 3/07/13 → 7/07/13 |
Internet address |