Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects

Erwin J. Van Drunen, Yeong Shiong Chiew, J. Geoffrey Chase, Bernard Lambermont, Nathalie Janssen, Thomas Desaive

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

9 Citations (Scopus)

Abstract

Modelling the respiratory mechanics of mechanically ventilated (MV) patients can provide useful information to guide MV therapy. Two model-based methods were evaluated based on data from three experimental acute respiratory distress syndrome (ARDS) induced piglets and validated against values available from ventilators. A single compartment lung model with integral-based parameter identification was found to be effective in capturing fundamental respiratory mechanics during inspiration. The trends matched clinical expectation and provided better resolution than clinically derived linear model metrics. An expiration time constant model also captured the same trend in respiratory elastance. However, the assumption of constant resistance and a slightly higher fitting error results in less insight than the single compartment model. Further research is required to confirm its application in titrating to optimal MV settings.

Original languageEnglish
Title of host publication2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Pages5224-5227
Number of pages4
DOIs
Publication statusPublished - 2013
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2013 - Osaka International Convention Center, Osaka, Japan
Duration: 3 Jul 20137 Jul 2013
Conference number: 35th
https://ieeexplore.ieee.org/xpl/conhome/6596169/proceeding (Proceedings)

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2013
Abbreviated titleEMBC 2013
CountryJapan
CityOsaka
Period3/07/137/07/13
Internet address

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