Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects

Erwin J. Van Drunen; Yeong Shiong Chiew; J. Geoffrey Chase; Bernard Lambermont; Nathalie Janssen; Thomas Desaive

doi:10.1109/EMBC.2013.6610726

Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects

Erwin J. Van Drunen, Yeong Shiong Chiew, J. Geoffrey Chase, Bernard Lambermont, Nathalie Janssen, Thomas Desaive

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

9 Citations (Scopus)

Abstract

Modelling the respiratory mechanics of mechanically ventilated (MV) patients can provide useful information to guide MV therapy. Two model-based methods were evaluated based on data from three experimental acute respiratory distress syndrome (ARDS) induced piglets and validated against values available from ventilators. A single compartment lung model with integral-based parameter identification was found to be effective in capturing fundamental respiratory mechanics during inspiration. The trends matched clinical expectation and provided better resolution than clinically derived linear model metrics. An expiration time constant model also captured the same trend in respiratory elastance. However, the assumption of constant resistance and a slightly higher fitting error results in less insight than the single compartment model. Further research is required to confirm its application in titrating to optimal MV settings.

Original language	English
Title of host publication	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Pages	5224-5227
Number of pages	4
DOIs	https://doi.org/10.1109/EMBC.2013.6610726
Publication status	Published - 2013
Externally published	Yes
Event	International Conference of the IEEE Engineering in Medicine and Biology Society 2013 - Osaka International Convention Center, Osaka, Japan Duration: 3 Jul 2013 → 7 Jul 2013 Conference number: 35th https://ieeexplore.ieee.org/xpl/conhome/6596169/proceeding (Proceedings)

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Conference

Conference	International Conference of the IEEE Engineering in Medicine and Biology Society 2013
Abbreviated title	EMBC 2013
Country	Japan
City	Osaka
Period	3/07/13 → 7/07/13
Internet address	https://ieeexplore.ieee.org/xpl/conhome/6596169/proceeding (Proceedings)

Access to Document

10.1109/EMBC.2013.6610726

Link to publication in Scopus

Cite this

Van Drunen, E. J., Chiew, Y. S., Chase, J. G., Lambermont, B., Janssen, N., & Desaive, T. (2013). Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 (pp. 5224-5227). (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6610726

Van Drunen, Erwin J. ; Chiew, Yeong Shiong ; Chase, J. Geoffrey ; Lambermont, Bernard ; Janssen, Nathalie ; Desaive, Thomas. / Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. pp. 5224-5227 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects",

abstract = "Modelling the respiratory mechanics of mechanically ventilated (MV) patients can provide useful information to guide MV therapy. Two model-based methods were evaluated based on data from three experimental acute respiratory distress syndrome (ARDS) induced piglets and validated against values available from ventilators. A single compartment lung model with integral-based parameter identification was found to be effective in capturing fundamental respiratory mechanics during inspiration. The trends matched clinical expectation and provided better resolution than clinically derived linear model metrics. An expiration time constant model also captured the same trend in respiratory elastance. However, the assumption of constant resistance and a slightly higher fitting error results in less insight than the single compartment model. Further research is required to confirm its application in titrating to optimal MV settings.",

author = "{Van Drunen}, {Erwin J.} and Chiew, {Yeong Shiong} and Chase, {J. Geoffrey} and Bernard Lambermont and Nathalie Janssen and Thomas Desaive",

note = "Copyright: Copyright 2013 Elsevier B.V., All rights reserved.; International Conference of the IEEE Engineering in Medicine and Biology Society 2013, EMBC 2013 ; Conference date: 03-07-2013 Through 07-07-2013",

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Van Drunen, EJ, Chiew, YS, Chase, JG, Lambermont, B, Janssen, N & Desaive, T 2013, Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects. in 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 5224-5227, International Conference of the IEEE Engineering in Medicine and Biology Society 2013, Osaka, Japan, 3/07/13. https://doi.org/10.1109/EMBC.2013.6610726

Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects. / Van Drunen, Erwin J.; Chiew, Yeong Shiong; Chase, J. Geoffrey; Lambermont, Bernard; Janssen, Nathalie; Desaive, Thomas.

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 5224-5227 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

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T1 - Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects

AU - Van Drunen, Erwin J.

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AU - Lambermont, Bernard

AU - Janssen, Nathalie

AU - Desaive, Thomas

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AB - Modelling the respiratory mechanics of mechanically ventilated (MV) patients can provide useful information to guide MV therapy. Two model-based methods were evaluated based on data from three experimental acute respiratory distress syndrome (ARDS) induced piglets and validated against values available from ventilators. A single compartment lung model with integral-based parameter identification was found to be effective in capturing fundamental respiratory mechanics during inspiration. The trends matched clinical expectation and provided better resolution than clinically derived linear model metrics. An expiration time constant model also captured the same trend in respiratory elastance. However, the assumption of constant resistance and a slightly higher fitting error results in less insight than the single compartment model. Further research is required to confirm its application in titrating to optimal MV settings.

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Van Drunen EJ, Chiew YS, Chase JG, Lambermont B, Janssen N, Desaive T. Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 5224-5227. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6610726