Mixed alkoxy/hydroxy 1,8-naphthalimides: expanded fluorescence colour palette and: In vitro bioactivity

Elley E. Rudebeck, Rosalind P. Cox, Toby D.M. Bell, Rameshwor Acharya, Zikai Feng, Nuri Gueven, Trent D. Ashton, Frederick M. Pfeffer

Research output: Contribution to journalArticleOtherpeer-review

15 Citations (Scopus)


An efficient and functional group tolerant route to access hydroxy 1,8-naphthalimides has been used to synthesise a range of mono- and disubstituted hydroxy-1,8-naphthalimides with fluorescence emissions covering the visible spectrum. The dialkoxy substituted compounds prepared possess high quantum yields (up to 0.95) and long fluorescent lifetimes (up to 14 ns). The method has been used to generate scriptaid analogues that successfully inhibit HDAC6 in vitro with tubulin acetylation assays confirming that these compounds are more effective than tubastatin.

Original languageEnglish
Pages (from-to)6866-6869
Number of pages4
JournalChemical Communications
Issue number50
Publication statusPublished - 25 Jun 2020

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