Mitophagy and mitoptosis in disease processes

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Mitochondria play a very important role in cellular function, not only through key metabolic reactions and energy generation, but also by being a major site for production of reactive oxygen species and a key player in cell death. Therefore, mitochondrial dysfunction or damage may have severe consequences. Mitophagy (autophagic degradation of mitochondria) and mitoptosis (programmed destruction of mitochondria) are the processes by which cells can deal with impaired mitochondria. The efficiency of these processes may be a contributing factor to the pathogenesis of various diseases.
Original languageEnglish
Title of host publicationProtein Misfolding and Cellular Stress in Disease and Aging: Concepts and Protocols
EditorsPeter Bross, Niels Gregersen
Place of PublicationUK
PublisherHumana Press
Pages93 - 106
Number of pages14
ISBN (Print)9781607617556
Publication statusPublished - 2010

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