Abstract
| Original language | English |
|---|---|
| Title of host publication | Autophagy - Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging - Volume 4 |
| Editors | M A Hayat |
| Place of Publication | USA |
| Publisher | Academic Press |
| Pages | 103 - 116 |
| Number of pages | 14 |
| ISBN (Print) | 9780124055285 |
| DOIs | |
| Publication status | Published - 2014 |
Cite this
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Mitophagy: an overview. / Mijaljica, Dalibor; Prescott, Mark; Devenish, Rodney James.
Autophagy - Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging - Volume 4. ed. / M A Hayat. USA : Academic Press, 2014. p. 103 - 116.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
TY - CHAP
T1 - Mitophagy: an overview
AU - Mijaljica, Dalibor
AU - Prescott, Mark
AU - Devenish, Rodney James
PY - 2014
Y1 - 2014
N2 - Mitochondria play an important role in a number of processes that are essential to the life of cells as well as being key players in cell death mechanisms. The removal (elimination/degradation) of mitochondria through a selective autophagy, known as mitophagy, is critical for maintaining proper metabolic function and control at both the mitochondrial and cellular levels. Mitophagy can be triggered by diverse signals in the context of either a specific physiologic requirement for the removal of mitochondria (e.g., maturation of erythrocytes), or in disease situations in order to limit the effects arising from the presence of damaged mitochondria. In this chapter, we provide an overview of recent progress in understanding of the mechanisms of mitophagy and their regulation by considering both physiological and pathological roles of mitophagy including development, aging, cancer, neurodegenerative diseases, infection, and inflammation.
AB - Mitochondria play an important role in a number of processes that are essential to the life of cells as well as being key players in cell death mechanisms. The removal (elimination/degradation) of mitochondria through a selective autophagy, known as mitophagy, is critical for maintaining proper metabolic function and control at both the mitochondrial and cellular levels. Mitophagy can be triggered by diverse signals in the context of either a specific physiologic requirement for the removal of mitochondria (e.g., maturation of erythrocytes), or in disease situations in order to limit the effects arising from the presence of damaged mitochondria. In this chapter, we provide an overview of recent progress in understanding of the mechanisms of mitophagy and their regulation by considering both physiological and pathological roles of mitophagy including development, aging, cancer, neurodegenerative diseases, infection, and inflammation.
UR - https://www.elsevier.com/books/autophagy-cancer-other-pathologies-inflammation-immunity-infection-and-aging/hayat/978-0-12-405877-4
U2 - 10.1016/B978-0-12-405528-5.00005-5
DO - 10.1016/B978-0-12-405528-5.00005-5
M3 - Chapter (Book)
SN - 9780124055285
SP - 103
EP - 116
BT - Autophagy - Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging - Volume 4
A2 - Hayat, M A
PB - Academic Press
CY - USA
ER -