Mitochondria play an important role in a number of processes that are essential to the life of cells as well as being key players in cell death mechanisms. The removal (elimination/degradation) of mitochondria through a selective autophagy, known as mitophagy, is critical for maintaining proper metabolic function and control at both the mitochondrial and cellular levels. Mitophagy can be triggered by diverse signals in the context of either a specific physiologic requirement for the removal of mitochondria (e.g., maturation of erythrocytes), or in disease situations in order to limit the effects arising from the presence of damaged mitochondria. In this chapter, we provide an overview of recent progress in understanding of the mechanisms of mitophagy and their regulation by considering both physiological and pathological roles of mitophagy including development, aging, cancer, neurodegenerative diseases, infection, and inflammation.
|Title of host publication||Autophagy - Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging - Volume 4|
|Editors||M A Hayat|
|Place of Publication||USA|
|Pages||103 - 116|
|Number of pages||14|
|Publication status||Published - 2014|