Mitochondrial protein-import machinery: correlating structure with function

Michael J. Baker, Ann E. Frazier, Jacqueline M. Gulbis, Michael T. Ryan

Research output: Contribution to journalReview ArticleResearchpeer-review

126 Citations (Scopus)

Abstract

Most mitochondrial proteins are synthesized in the cytosol, translocated into the organelle and directed along specific sorting pathways. Over the past 20 years, >30 proteins have been identified as having key roles in mitochondrial protein import. Recently, the elucidation of the structures of several import components has provided fresh insight into the import process. Here, we review the different pathways involved in sorting proteins into mitochondrial subcompartments. Along the way, we highlight the available structural information about the protein-import machinery and discuss how these structures correlate with previously ascribed functions. Future challenges for the cell biologists will be to use this structural information to test specific hypotheses addressing the molecular mechanisms of mitochondrial protein import.

Original languageEnglish
Pages (from-to)456-464
Number of pages9
JournalTrends in Cell Biology
Volume17
Issue number9
DOIs
Publication statusPublished - 1 Sep 2007
Externally publishedYes

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