Mitochondrial-nuclear communications

Michael T. Ryan, Nicholas J. Hoogenraad

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

486 Citations (Scopus)


Mitochondria cannot be made de novo but replicate by a mechanism of recruitment of new proteins, which are added to preexisting sub- compartments. Although mitochondria have their own DNA, more than 98% of the total protein complement of the organelle is encoded by the nuclear genome. Mitochondrial biogenesis requires a coordination of expression of two genomes and therefore cross talk between the nucleus and mitochondria. In mammals, regulation of mitochondrial biogenesis and proliferation is influenced by external factors, such as nutrients, hormones, temperature, exercise, hypoxia, and aging. This complexity points to the existence of a coordinated and tightly regulated network connecting different pathways. Communications are also required for eliciting mitochondrial responses to specific stress pathways. This review covers the mechanisms of mi- tochondrial biogenesis and the way cells respond to external signals to maintain mitochondrial function and cellular homeostasis.

Original languageEnglish
Title of host publicationAnnual Review of Biochemistry
Number of pages22
Publication statusPublished - 1 Dec 2007
Externally publishedYes

Publication series

NameAnnual Review of Biochemistry
ISSN (Print)0066-4154
ISSN (Electronic)0066-4154


  • Mitochondrial biogenesis
  • Mitochondrial stress response
  • Retrograde signaling

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