Mitochondrial genomes of Trichinella species and genotypes - a basis for diagnosis, and systematic and epidemiological explorations

Namitha Mohandas, Edoardo Pozio, Giuseppe La Rosa, Pasi K Korhonen, Neil David Young, Anson V Koehler, Ross S Hall, Paul W Sternberg, Peter Robert Boag, Aaron R Jex, Bill C H Chang, Robin B Gasser

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

In the present study we sequenced or re-sequenced, assembled and annotated 15 mitochondrial genomes representing the 12 currently recognised taxa of Trichinella using a deep sequencing-coupled approach. We then defined and compared the gene order in individual mitochondrial genomes ( approximately 14 to 17.7kb), evaluated genetic differences among species/genotypes and re-assessed the relationships among these taxa using the mitochondrial nucleic acid or amino acid sequence data sets. In addition, a rich source of mitochondrial genetic markers was defined that could be used in future systematic, epidemiological and population genetic studies of Trichinella. The sequencing-bioinformatic approach employed herein should be applicable to a wide range of eukaryotic parasites.
Original languageEnglish
Pages (from-to)1073 - 1080
Number of pages8
JournalInternational Journal for Parasitology
Volume44
Issue number14
DOIs
Publication statusPublished - 2014

Cite this