|Title of host publication||Encyclopedia of Life Sciences|
|Place of Publication||Chichester|
|Publisher||John Wiley & Sons|
|Number of pages||7|
|Publication status||Published - 15 Jan 2016|
The mitochondria are a multifaceted organelle,central to the function of all eukaryotic cells.Mitochondria are critical to cell metabolism andcritical for regulation of intrinsic cell death pathways.This balance between life and death is reliant on the process of mitochondrial fission and fusion,constantly joining and separating to maintain the mitochondrial network within the cell and to facilitate cellular events such as mitosis, biogenesis and maintenance of mitochondrial integrity viamitophagy. The dynamic fluctuations in the architecture of these organelles is garnering increased attention across a broad range of disciplines and diseases. Such diseases include genetic disorders such as Charcot-Marie-Tooth disease type 2A and autosomal-dominant optic atrophy, as well as pathologies associated with mitochondrial dysfunction such as chronic neurodegeneration such as Parkinson disease, type 2 diabetes and various forms of chronic and acute kidney injury.
- Mitochondrial diseases
- Cell biology