Mitochondrial Fission/Fusion and Disease

Gavin C Higgins, Melinda T Coughlan

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review


The mitochondria are a multifaceted organelle,central to the function of all eukaryotic cells.Mitochondria are critical to cell metabolism andcritical for regulation of intrinsic cell death pathways.This balance between life and death is reliant on the process of mitochondrial fission and fusion,constantly joining and separating to maintain the mitochondrial network within the cell and to facilitate cellular events such as mitosis, biogenesis and maintenance of mitochondrial integrity viamitophagy. The dynamic fluctuations in the architecture of these organelles is garnering increased attention across a broad range of disciplines and diseases. Such diseases include genetic disorders such as Charcot-Marie-Tooth disease type 2A and autosomal-dominant optic atrophy, as well as pathologies associated with mitochondrial dysfunction such as chronic neurodegeneration such as Parkinson disease, type 2 diabetes and various forms of chronic and acute kidney injury.
Original languageEnglish
Title of host publicationEncyclopedia of Life Sciences
Place of PublicationChichester
PublisherJohn Wiley & Sons
Number of pages7
Publication statusPublished - 15 Jan 2016
Externally publishedYes


  • Mitochondrial diseases
  • Cell biology

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