Mitochondrial DNA sequence analysis in congenital myotonic dystrophy

D. Thyagarajan, E. Byrne, S. Noer, P. Lertrit, P. Utthanophol, R. Kapsa, S. Marzuki

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Mitochondrial genetic modifying factors have been suspected in several autosomally inherited diseases. The congenital variant of myotonic dystrophy, in which there is a striking maternal inheritance pattern, is a likely candidate disease. To investigate this possibility, we sequenced completely the mitochondrial genome in 2 patients with congential myotonic dystrophy. Comparison of the two sequences with control data failed to reveal a specific nucleotide variant or length variant in this disease. We conclude that a mitochondrial genetic modifying factor is not present in congenital myotonic dystrophy.

Original languageEnglish
Pages (from-to)724-727
Number of pages4
JournalAnnals of Neurology
Issue number5
Publication statusPublished - Nov 1991

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