@article{cb3a645fd0dc4fa5a821ae503123b0a4,
title = "Mitochondrial degradation: Mitophagy and beyond",
abstract = "Mitochondria are central hubs of cellular metabolism that also play key roles in signaling and disease. It is therefore fundamentally important that mitochondrial quality and activity are tightly regulated. Mitochondrial degradation pathways contribute to quality control of mitochondrial networks and can also regulate the metabolic profile of mitochondria to ensure cellular homeostasis. Here, we cover the many and varied ways in which cells degrade or remove their unwanted mitochondria, ranging from mitophagy to mitochondrial extrusion. The molecular signals driving these varied pathways are discussed, including the cellular and physiological contexts under which the different degradation pathways are engaged.",
keywords = "degradation, MDV, mitochondria, mitochondrial quality control, mitophagy, Parkin, PINK1, proteasome, selective autophagy, ubiquitin",
author = "Louise Uoselis and Nguyen, {Thanh Ngoc} and Michael Lazarou",
note = "Funding Information: The study is funded by the joint efforts of The Michael J. Fox Foundation for Parkinson{\textquoteright}s Research (MJFF) and the Aligning Science Across Parkinson{\textquoteright}s (ASAP) initiative . MJFF administers the grant ASAP-000350 on behalf of ASAP and itself. M.L. is also supported by the National Health and Medical Research Council (NHMRC) ( GNT1106471 ) and the Australian Research Council (ARC) Discovery Project ( DP200100347 ). We thank Tahnee Saunders for critical reading of the manuscript and for generating the general outline of the review. Funding Information: The study is funded by the joint efforts of The Michael J. Fox Foundation for Parkinson's Research (MJFF) and the Aligning Science Across Parkinson's (ASAP) initiative. MJFF administers the grant ASAP-000350 on behalf of ASAP and itself. M.L. is also supported by the National Health and Medical Research Council (NHMRC) (GNT1106471) and the Australian Research Council (ARC) Discovery Project (DP200100347). We thank Tahnee Saunders for critical reading of the manuscript and for generating the general outline of the review. M.L. is a co-founder and scientific advisory board member of Automera. Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = oct,
day = "5",
doi = "10.1016/j.molcel.2023.08.021",
language = "English",
volume = "83",
pages = "3404--3420",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Elsevier",
number = "19",
}