Mitochondrial Control of Fungal Cell Walls: Models and Relevance in Fungal Pathogens

Barbara Koch, Ana Traven

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Abstract

Proper structure and function of the fungal cell wall are controlled by metabolic processes, as well as an interplay between a range of cellular organelles. Somewhat surprisingly, mitochondrial function has been shown to be important for proper cell wall biogenesis and integrity. Mitochondria also play a role in the susceptibility of fungi to cell wall-targeting drugs. This is true in a range of fungal species, including important human fungal pathogens. The biochemical mechanisms that explain the roles of mitochondria in cell wall biology have remained elusive, but studies to date strongly support the idea that mitochondrial control over cellular lipid homeostasis is at the core of these processes. Excitingly, recent evidence suggests that the mitochondria-lipid linkages drive resistance to the echinocandin drug caspofungin, a clinically important therapeutic that targets cell wall biosynthesis. Here, we review the state of affairs in mitochondria-fungal cell wall research and propose models that could be tested in future studies. Elucidating the mechanisms that drive fungal cell wall integrity through mitochondrial functions holds promise for developing new strategies to combat fungal infections, including the possibility to potentiate the effects of antifungal drugs and curb drug resistance.

Original languageEnglish
Title of host publicationThe Fungal Cell Wall
Subtitle of host publicationAn Armour and a Weapon for Human Fungal Pathogens
EditorsJean-Paul Latge
Place of PublicationSwitzerland
PublisherSpringer
Pages277-296
Number of pages20
ISBN (Electronic)9783030499280
ISBN (Print)9783030499273
DOIs
Publication statusPublished - 2020

Publication series

NameCurrent Topics in Microbiology and Immunology
PublisherSpringer
Volume425
ISSN (Print)0070-217X
ISSN (Electronic)2196-9965

Cite this

Koch, B., & Traven, A. (2020). Mitochondrial Control of Fungal Cell Walls: Models and Relevance in Fungal Pathogens. In J-P. Latge (Ed.), The Fungal Cell Wall: An Armour and a Weapon for Human Fungal Pathogens (pp. 277-296). (Current Topics in Microbiology and Immunology; Vol. 425). Springer. https://doi.org/10.1007/82_2019_183