Mitigation of Amyloidosis with Nanomaterials

Pu Chun Ke, Emily H. Pilkington, Yunxiang Sun, Ibrahim Javed, Aleksandr Kakinen, Guotao Peng, Feng Ding, Thomas P. Davis

Research output: Contribution to journalReview ArticleResearchpeer-review

18 Citations (Scopus)

Abstract

Amyloidosis is a biophysical phenomenon of protein aggregation with biological and pathogenic implications. Among the various strategies developed to date, nanomaterials and multifunctional nanocomposites possessing certain structural and physicochemical traits are promising candidates for mitigating amyloidosis in vitro and in vivo. The mechanisms underpinning protein aggregation and toxicity are introduced, and opportunities in materials science to drive this interdisciplinary field forward are highlighted. Advancement of this emerging frontier hinges on exploitation of protein self-assembly and interactions of amyloid proteins with nanoparticles, intracellular and extracellular proteins, chaperones, membranes, organelles, and biometals.

Original languageEnglish
Article number1901690
Number of pages7
JournalAdvanced Materials
Volume32
Issue number18
DOIs
Publication statusPublished - 7 May 2020

Keywords

  • amyloidosis
  • nanocomposites
  • nanomaterials
  • oligomers

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