Mitigation of Amyloidosis with Nanomaterials

Pu Chun Ke, Emily H. Pilkington, Yunxiang Sun, Ibrahim Javed, Aleksandr Kakinen, Guotao Peng, Feng Ding, Thomas P. Davis

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Amyloidosis is a biophysical phenomenon of protein aggregation with biological and pathogenic implications. Among the various strategies developed to date, nanomaterials and multifunctional nanocomposites possessing certain structural and physicochemical traits are promising candidates for mitigating amyloidosis in vitro and in vivo. The mechanisms underpinning protein aggregation and toxicity are introduced, and opportunities in materials science to drive this interdisciplinary field forward are highlighted. Advancement of this emerging frontier hinges on exploitation of protein self-assembly and interactions of amyloid proteins with nanoparticles, intracellular and extracellular proteins, chaperones, membranes, organelles, and biometals.

Original languageEnglish
Article number1901690
Number of pages7
JournalAdvanced Materials
Volume31
Issue number35
DOIs
Publication statusPublished - 2019

Keywords

  • amyloidosis
  • nanocomposites
  • nanomaterials
  • oligomers

Cite this

Ke, Pu Chun ; Pilkington, Emily H. ; Sun, Yunxiang ; Javed, Ibrahim ; Kakinen, Aleksandr ; Peng, Guotao ; Ding, Feng ; Davis, Thomas P. / Mitigation of Amyloidosis with Nanomaterials. In: Advanced Materials. 2019 ; Vol. 31, No. 35.
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Ke, PC, Pilkington, EH, Sun, Y, Javed, I, Kakinen, A, Peng, G, Ding, F & Davis, TP 2019, 'Mitigation of Amyloidosis with Nanomaterials', Advanced Materials, vol. 31, no. 35, 1901690. https://doi.org/10.1002/adma.201901690

Mitigation of Amyloidosis with Nanomaterials. / Ke, Pu Chun; Pilkington, Emily H.; Sun, Yunxiang; Javed, Ibrahim; Kakinen, Aleksandr; Peng, Guotao; Ding, Feng; Davis, Thomas P.

In: Advanced Materials, Vol. 31, No. 35, 1901690, 2019.

Research output: Contribution to journalReview ArticleResearchpeer-review

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T1 - Mitigation of Amyloidosis with Nanomaterials

AU - Ke, Pu Chun

AU - Pilkington, Emily H.

AU - Sun, Yunxiang

AU - Javed, Ibrahim

AU - Kakinen, Aleksandr

AU - Peng, Guotao

AU - Ding, Feng

AU - Davis, Thomas P.

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