Mirtazapine antagonises the subjective, hormonal and neuronal effects of m-chlorophenylpiperazine (mCPP) infusion: A pharmacological-challenge fMRI (phMRI) study

Shane McKie, Paul Richardson, Rebecca Elliott, Birgit A Vollm, Margaret (Mairead) Dolan, Steve R Williams, Ian M Anderson, John F W Deakin

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)


In the current study we determined whether BOLD signal responses to mCPP could be blocked by pre-treatment with a 5-HT2C antagonist. Healthy male volunteers received oral mirtazapine, 5-HT2/5-HT3 receptor antagonist, or placebo 90 min prior to intravenous mCPP challenge phMRI. BOLD signal increases following mCPP infusion occurred in areas known to be rich in 5-HT2C receptors such as the substantia nigra, hypothalamus, pallidum and amygdala. These responses were attenuated by mirtazapine pre-treatment. The results suggest that mCPP-challenge phMRI produces reliable patterns of response that are mediated by 5-HT2C receptors; these responses may therefore be useful in-vivo measures of 5-HT2C function in psychiatric disorders
Original languageEnglish
Pages (from-to)497 - 507
Number of pages11
Issue number2
Publication statusPublished - 2011

Cite this