Mirnas: Small genes with big potential in metazoan phylogenetics

James E. Tarver, Erik A. Sperling, Audrey Nailor, Alysha M. Heimberg, Jeffrey M. Robinson, Benjamin L. King, Davide Pisani, Philip C.J. Donoghue, Kevin J. Peterson

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Abstract

microRNAs (miRNAs) are a key component of gene regulatory networks and have been implicated in the regulation of virtually every biological process found in multicellular eukaryotes. What makes them interesting from a phylogenetic perspective is the high conservation of primary sequence between taxa, their accrual in metazoan genomes through evolutionary time, and the rarity of secondary loss inmost metazoan taxa. Despite these properties, the use of miRNAs as phylogenetic markers has not yet been discussed within a clear conceptual framework. Here we highlight five properties of miRNAs that underlie their utility in phylogenetics: 1) The processes of miRNA biogenesis enable the identification of novelmiRNAs without prior knowledge of sequence; 2) The continuous addition ofmiRNA families tometazoan genomes through evolutionary time; 3) The low level of secondary gene loss in most metazoan taxa; 4) The low substitution rate in the maturemiRNA sequence; and 5) The small probability of convergent evolution of two miRNAs. Phylogenetic analyses using both Bayesian and parsimony methods on a eumetazoan miRNA data set highlight the potential of miRNAs to become an invaluable new tool, especially when used as an additional line of evidence, to resolve previously intractable nodes within the tree of life.

Original languageEnglish
Pages (from-to)2369-2382
Number of pages14
JournalMolecular Biology and Evolution
Volume30
Issue number11
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Microrna
  • Phylogenetics
  • Rare genomic character

Cite this

Tarver, J. E., Sperling, E. A., Nailor, A., Heimberg, A. M., Robinson, J. M., King, B. L., ... Peterson, K. J. (2013). Mirnas: Small genes with big potential in metazoan phylogenetics. Molecular Biology and Evolution, 30(11), 2369-2382. https://doi.org/10.1093/molbev/mst133
Tarver, James E. ; Sperling, Erik A. ; Nailor, Audrey ; Heimberg, Alysha M. ; Robinson, Jeffrey M. ; King, Benjamin L. ; Pisani, Davide ; Donoghue, Philip C.J. ; Peterson, Kevin J. / Mirnas : Small genes with big potential in metazoan phylogenetics. In: Molecular Biology and Evolution. 2013 ; Vol. 30, No. 11. pp. 2369-2382.
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Tarver, JE, Sperling, EA, Nailor, A, Heimberg, AM, Robinson, JM, King, BL, Pisani, D, Donoghue, PCJ & Peterson, KJ 2013, 'Mirnas: Small genes with big potential in metazoan phylogenetics', Molecular Biology and Evolution, vol. 30, no. 11, pp. 2369-2382. https://doi.org/10.1093/molbev/mst133

Mirnas : Small genes with big potential in metazoan phylogenetics. / Tarver, James E.; Sperling, Erik A.; Nailor, Audrey; Heimberg, Alysha M.; Robinson, Jeffrey M.; King, Benjamin L.; Pisani, Davide; Donoghue, Philip C.J.; Peterson, Kevin J.

In: Molecular Biology and Evolution, Vol. 30, No. 11, 11.2013, p. 2369-2382.

Research output: Contribution to journalArticleResearchpeer-review

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Tarver JE, Sperling EA, Nailor A, Heimberg AM, Robinson JM, King BL et al. Mirnas: Small genes with big potential in metazoan phylogenetics. Molecular Biology and Evolution. 2013 Nov;30(11):2369-2382. https://doi.org/10.1093/molbev/mst133