MiRNAs and diabetes mellitus

Dwi Setyowati Karolina, Arunmozhiarasi Armugam, Sugunavathi Sepramaniam, Kandiah Jeyaseelan

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Diabetes is a chronic disease that manifests when insulin production by the pancreas is insufficient or when the body cannot effectively utilize the secreted insulin. The onset of diabetes often goes undetected until the later stages where subsequent glucose accumulation in the system (hyperglycemia) is observed. Over time, it leads to serious multi-organ damage, especially to the nerves and blood vessels. The WHO reports that approximately 346 million people worldwide are diagnosed with diabetes. With no cure available, long-term medical care for diabetes has become a global economic challenge globally. Hence, there is a need to explore novel early biomarkers and therapeutics for diabetes. One such potential molecule is the miRNAs. miRNAs are endogenous, noncoding RNAs that predominantly inhibit gene expression. Compelling evidence showed that altered miRNA expressions are linked to pathological conditions, including diabetes manifestation. This review focuses on the implications of miRNAs in diabetes and their related complications.

Original languageEnglish
Pages (from-to)281-300
Number of pages20
JournalExpert Review of Endocrinology and Metabolism
Volume7
Issue number3
DOIs
Publication statusPublished - May 2012
Externally publishedYes

Keywords

  • diabetes
  • gene regulators
  • insulin signaling
  • lipid metabolism
  • miRNAs

Cite this

Karolina, D. S., Armugam, A., Sepramaniam, S., & Jeyaseelan, K. (2012). MiRNAs and diabetes mellitus. Expert Review of Endocrinology and Metabolism, 7(3), 281-300. https://doi.org/10.1586/eem.12.21
Karolina, Dwi Setyowati ; Armugam, Arunmozhiarasi ; Sepramaniam, Sugunavathi ; Jeyaseelan, Kandiah. / MiRNAs and diabetes mellitus. In: Expert Review of Endocrinology and Metabolism. 2012 ; Vol. 7, No. 3. pp. 281-300.
@article{b889b77e6ee341b8a238d90789505d90,
title = "MiRNAs and diabetes mellitus",
abstract = "Diabetes is a chronic disease that manifests when insulin production by the pancreas is insufficient or when the body cannot effectively utilize the secreted insulin. The onset of diabetes often goes undetected until the later stages where subsequent glucose accumulation in the system (hyperglycemia) is observed. Over time, it leads to serious multi-organ damage, especially to the nerves and blood vessels. The WHO reports that approximately 346 million people worldwide are diagnosed with diabetes. With no cure available, long-term medical care for diabetes has become a global economic challenge globally. Hence, there is a need to explore novel early biomarkers and therapeutics for diabetes. One such potential molecule is the miRNAs. miRNAs are endogenous, noncoding RNAs that predominantly inhibit gene expression. Compelling evidence showed that altered miRNA expressions are linked to pathological conditions, including diabetes manifestation. This review focuses on the implications of miRNAs in diabetes and their related complications.",
keywords = "diabetes, gene regulators, insulin signaling, lipid metabolism, miRNAs",
author = "Karolina, {Dwi Setyowati} and Arunmozhiarasi Armugam and Sugunavathi Sepramaniam and Kandiah Jeyaseelan",
year = "2012",
month = "5",
doi = "10.1586/eem.12.21",
language = "English",
volume = "7",
pages = "281--300",
journal = "Expert Review of Endocrinology and Metabolism",
issn = "1744-6651",
publisher = "Taylor & Francis",
number = "3",

}

Karolina, DS, Armugam, A, Sepramaniam, S & Jeyaseelan, K 2012, 'MiRNAs and diabetes mellitus', Expert Review of Endocrinology and Metabolism, vol. 7, no. 3, pp. 281-300. https://doi.org/10.1586/eem.12.21

MiRNAs and diabetes mellitus. / Karolina, Dwi Setyowati; Armugam, Arunmozhiarasi; Sepramaniam, Sugunavathi; Jeyaseelan, Kandiah.

In: Expert Review of Endocrinology and Metabolism, Vol. 7, No. 3, 05.2012, p. 281-300.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - MiRNAs and diabetes mellitus

AU - Karolina, Dwi Setyowati

AU - Armugam, Arunmozhiarasi

AU - Sepramaniam, Sugunavathi

AU - Jeyaseelan, Kandiah

PY - 2012/5

Y1 - 2012/5

N2 - Diabetes is a chronic disease that manifests when insulin production by the pancreas is insufficient or when the body cannot effectively utilize the secreted insulin. The onset of diabetes often goes undetected until the later stages where subsequent glucose accumulation in the system (hyperglycemia) is observed. Over time, it leads to serious multi-organ damage, especially to the nerves and blood vessels. The WHO reports that approximately 346 million people worldwide are diagnosed with diabetes. With no cure available, long-term medical care for diabetes has become a global economic challenge globally. Hence, there is a need to explore novel early biomarkers and therapeutics for diabetes. One such potential molecule is the miRNAs. miRNAs are endogenous, noncoding RNAs that predominantly inhibit gene expression. Compelling evidence showed that altered miRNA expressions are linked to pathological conditions, including diabetes manifestation. This review focuses on the implications of miRNAs in diabetes and their related complications.

AB - Diabetes is a chronic disease that manifests when insulin production by the pancreas is insufficient or when the body cannot effectively utilize the secreted insulin. The onset of diabetes often goes undetected until the later stages where subsequent glucose accumulation in the system (hyperglycemia) is observed. Over time, it leads to serious multi-organ damage, especially to the nerves and blood vessels. The WHO reports that approximately 346 million people worldwide are diagnosed with diabetes. With no cure available, long-term medical care for diabetes has become a global economic challenge globally. Hence, there is a need to explore novel early biomarkers and therapeutics for diabetes. One such potential molecule is the miRNAs. miRNAs are endogenous, noncoding RNAs that predominantly inhibit gene expression. Compelling evidence showed that altered miRNA expressions are linked to pathological conditions, including diabetes manifestation. This review focuses on the implications of miRNAs in diabetes and their related complications.

KW - diabetes

KW - gene regulators

KW - insulin signaling

KW - lipid metabolism

KW - miRNAs

UR - http://www.scopus.com/inward/record.url?scp=84862096597&partnerID=8YFLogxK

U2 - 10.1586/eem.12.21

DO - 10.1586/eem.12.21

M3 - Review Article

VL - 7

SP - 281

EP - 300

JO - Expert Review of Endocrinology and Metabolism

JF - Expert Review of Endocrinology and Metabolism

SN - 1744-6651

IS - 3

ER -

Karolina DS, Armugam A, Sepramaniam S, Jeyaseelan K. MiRNAs and diabetes mellitus. Expert Review of Endocrinology and Metabolism. 2012 May;7(3):281-300. https://doi.org/10.1586/eem.12.21