Abstract
Diabetes is a chronic disease that manifests when insulin production by the pancreas is insufficient or when the body cannot effectively utilize the secreted insulin. The onset of diabetes often goes undetected until the later stages where subsequent glucose accumulation in the system (hyperglycemia) is observed. Over time, it leads to serious multi-organ damage, especially to the nerves and blood vessels. The WHO reports that approximately 346 million people worldwide are diagnosed with diabetes. With no cure available, long-term medical care for diabetes has become a global economic challenge globally. Hence, there is a need to explore novel early biomarkers and therapeutics for diabetes. One such potential molecule is the miRNAs. miRNAs are endogenous, noncoding RNAs that predominantly inhibit gene expression. Compelling evidence showed that altered miRNA expressions are linked to pathological conditions, including diabetes manifestation. This review focuses on the implications of miRNAs in diabetes and their related complications.
| Original language | English |
|---|---|
| Pages (from-to) | 281-300 |
| Number of pages | 20 |
| Journal | Expert Review of Endocrinology and Metabolism |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2012 |
| Externally published | Yes |
Keywords
- diabetes
- gene regulators
- insulin signaling
- lipid metabolism
- miRNAs
Cite this
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MiRNAs and diabetes mellitus. / Karolina, Dwi Setyowati; Armugam, Arunmozhiarasi; Sepramaniam, Sugunavathi; Jeyaseelan, Kandiah.
In: Expert Review of Endocrinology and Metabolism, Vol. 7, No. 3, 05.2012, p. 281-300.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - MiRNAs and diabetes mellitus
AU - Karolina, Dwi Setyowati
AU - Armugam, Arunmozhiarasi
AU - Sepramaniam, Sugunavathi
AU - Jeyaseelan, Kandiah
PY - 2012/5
Y1 - 2012/5
N2 - Diabetes is a chronic disease that manifests when insulin production by the pancreas is insufficient or when the body cannot effectively utilize the secreted insulin. The onset of diabetes often goes undetected until the later stages where subsequent glucose accumulation in the system (hyperglycemia) is observed. Over time, it leads to serious multi-organ damage, especially to the nerves and blood vessels. The WHO reports that approximately 346 million people worldwide are diagnosed with diabetes. With no cure available, long-term medical care for diabetes has become a global economic challenge globally. Hence, there is a need to explore novel early biomarkers and therapeutics for diabetes. One such potential molecule is the miRNAs. miRNAs are endogenous, noncoding RNAs that predominantly inhibit gene expression. Compelling evidence showed that altered miRNA expressions are linked to pathological conditions, including diabetes manifestation. This review focuses on the implications of miRNAs in diabetes and their related complications.
AB - Diabetes is a chronic disease that manifests when insulin production by the pancreas is insufficient or when the body cannot effectively utilize the secreted insulin. The onset of diabetes often goes undetected until the later stages where subsequent glucose accumulation in the system (hyperglycemia) is observed. Over time, it leads to serious multi-organ damage, especially to the nerves and blood vessels. The WHO reports that approximately 346 million people worldwide are diagnosed with diabetes. With no cure available, long-term medical care for diabetes has become a global economic challenge globally. Hence, there is a need to explore novel early biomarkers and therapeutics for diabetes. One such potential molecule is the miRNAs. miRNAs are endogenous, noncoding RNAs that predominantly inhibit gene expression. Compelling evidence showed that altered miRNA expressions are linked to pathological conditions, including diabetes manifestation. This review focuses on the implications of miRNAs in diabetes and their related complications.
KW - diabetes
KW - gene regulators
KW - insulin signaling
KW - lipid metabolism
KW - miRNAs
UR - http://www.scopus.com/inward/record.url?scp=84862096597&partnerID=8YFLogxK
U2 - 10.1586/eem.12.21
DO - 10.1586/eem.12.21
M3 - Review Article
VL - 7
SP - 281
EP - 300
JO - Expert Review of Endocrinology and Metabolism
JF - Expert Review of Endocrinology and Metabolism
SN - 1744-6651
IS - 3
ER -