TY - JOUR
T1 - miRNA in Ischemic Heart Disease and Its Potential as Biomarkers
T2 - A Comprehensive Review
AU - Kong, Amanda Shen Yee
AU - Lai, Kok Song
AU - Lim, Swee Hua Erin
AU - Sivalingam, Sivakumar
AU - Loh, Jiun Yan
AU - Maran, Sathiya
N1 - Funding Information:
This research was funded by Program Inisiatif Dana Bagi Penggerak, Program SDG-WWF, grant number MA01MOF1.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/8
Y1 - 2022/8
N2 - Ischemic heart disease (IHD) constitutes the leading global cause of mortality and morbidity. Although significant progress has been achieved in the diagnosis, treatment, and prognosis of IHD, more robust diagnostic biomarkers and therapeutic interventions are still needed to circumvent the increasing incidence of IHD. MicroRNAs (miRNAs) are critical regulators of cardiovascular function and are involved in various facets of cardiovascular biology. While the knowledge of the role of miRNAs in IHD as diagnostic biomarkers has improved, research emphasis on how miRNAs can be effectively used for diagnosis and prognosis of IHD is crucial. This review provides an overview of the biology, therapeutic and diagnostic potential, as well as the caveats of using miRNAs in IHD based on existing research.
AB - Ischemic heart disease (IHD) constitutes the leading global cause of mortality and morbidity. Although significant progress has been achieved in the diagnosis, treatment, and prognosis of IHD, more robust diagnostic biomarkers and therapeutic interventions are still needed to circumvent the increasing incidence of IHD. MicroRNAs (miRNAs) are critical regulators of cardiovascular function and are involved in various facets of cardiovascular biology. While the knowledge of the role of miRNAs in IHD as diagnostic biomarkers has improved, research emphasis on how miRNAs can be effectively used for diagnosis and prognosis of IHD is crucial. This review provides an overview of the biology, therapeutic and diagnostic potential, as well as the caveats of using miRNAs in IHD based on existing research.
KW - cardiac biomarkers
KW - diagnostics
KW - ischemic heart disease
KW - microRNAs
KW - therapeutic targets
UR - https://www.scopus.com/pages/publications/85137126608
U2 - 10.3390/ijms23169001
DO - 10.3390/ijms23169001
M3 - Review Article
C2 - 36012267
AN - SCOPUS:85137126608
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 16
M1 - 9001
ER -