miRNA: A promising therapeutic target in cancer

Amrutha Menon, Noraini Abd-Aziz, Kanwal Khalid, Chit Laa Poh, Rakesh Naidu

Research output: Contribution to journalReview ArticleResearchpeer-review

68 Citations (Scopus)


microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by complementarity pairing. Since discovery, they have been reported to be involved in a variety of biological functions and pathologies including cancer. In cancer, they can act as a tumor suppressor or oncomiR depending on the cell type. Studies have shown that miRNA-based therapy, either by inhibiting an oncomiR or by inducing a tumor suppressor, is effective in cancer treatment. This review focusses on the role of miRNA in cancer, therapeutic approaches with miRNAs and how they can be effectively delivered into a system. We have also summarized the patents and clinical trials in progress for miRNA therapy.

Original languageEnglish
Article number11502
Number of pages29
JournalInternational Journal of Molecular Sciences
Issue number19
Publication statusPublished - Oct 2022


  • cancer
  • miRNA
  • miRNA delivery
  • oncomiR
  • therapy
  • tumor suppressor

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