miRNA: A promising therapeutic target in cancer

Amrutha Menon, Noraini Abd-Aziz, Kanwal Khalid, Chit Laa Poh, Rakesh Naidu

Research output: Contribution to journalReview ArticleResearchpeer-review

68 Citations (Scopus)

Abstract

microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by complementarity pairing. Since discovery, they have been reported to be involved in a variety of biological functions and pathologies including cancer. In cancer, they can act as a tumor suppressor or oncomiR depending on the cell type. Studies have shown that miRNA-based therapy, either by inhibiting an oncomiR or by inducing a tumor suppressor, is effective in cancer treatment. This review focusses on the role of miRNA in cancer, therapeutic approaches with miRNAs and how they can be effectively delivered into a system. We have also summarized the patents and clinical trials in progress for miRNA therapy.

Original languageEnglish
Article number11502
Number of pages29
JournalInternational Journal of Molecular Sciences
Volume23
Issue number19
DOIs
Publication statusPublished - Oct 2022

Keywords

  • cancer
  • miRNA
  • miRNA delivery
  • oncomiR
  • therapy
  • tumor suppressor

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