Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 947 - 954 |
| Number of pages | 8 |
| Journal | Biochimica et Biophysica Acta - Biomembranes |
| Volume | 1808 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2011 |
Cite this
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Minor modifications and major adaptations: The evolution of molecular machines driving mitochondrial protein import. / Hewitt, Victoria; Alcock, Felicity; Lithgow, Trevor.
In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1808, No. 3, 2011, p. 947 - 954.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Minor modifications and major adaptations: The evolution of molecular machines driving mitochondrial protein import
AU - Hewitt, Victoria
AU - Alcock, Felicity
AU - Lithgow, Trevor
PY - 2011
Y1 - 2011
N2 - Bacterial endosymbionts gave rise to mitochondria in a process that depended on the acquisition of protein import pathways. Modification and in some cases major re-tooling of the endosymbiont s cellular machinery produced these pathways, establishing mitochondria as organelles common to all eukaryotic cells. The legacy of this evolutionary tinkering can be seen in the homologies and structural similarities between mitochondrial protein import machinery and modern day bacterial proteins. Comparative analysis of these systems is revealing both possible routes for the evolution of the mitochondrial membrane translocases and a greater understanding of the mechanisms behind mitochondrial protein import.
AB - Bacterial endosymbionts gave rise to mitochondria in a process that depended on the acquisition of protein import pathways. Modification and in some cases major re-tooling of the endosymbiont s cellular machinery produced these pathways, establishing mitochondria as organelles common to all eukaryotic cells. The legacy of this evolutionary tinkering can be seen in the homologies and structural similarities between mitochondrial protein import machinery and modern day bacterial proteins. Comparative analysis of these systems is revealing both possible routes for the evolution of the mitochondrial membrane translocases and a greater understanding of the mechanisms behind mitochondrial protein import.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20659421
U2 - 10.1016/j.bbamem.2010.07.019
DO - 10.1016/j.bbamem.2010.07.019
M3 - Review Article
VL - 1808
SP - 947
EP - 954
JO - Biochimica et Biophysica Acta - Biomembranes
JF - Biochimica et Biophysica Acta - Biomembranes
SN - 0005-2736
IS - 3
ER -