Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity

Thomas J Oxley, Nicholas L Opie, Sam E. John, Gil S Rind, Stephen M Ronayne, Tracey L Wheeler, Jack W. Judy, Alan J McDonald, Anthony Dornom, Timothy J H Lovell, Christopher Steward, David J Garrett, Bradford A Moffat, Elaine H Lui, Nawaf Yassi, Bruce C V Campbell, Yan T Wong, Kate E Fox, Ewan S Nurse, Iwan E BennettSébastien H Bauquier, Kishan A. Liyanage, Nicole R. Van Der Nagel, Piero Perucca, Arman Ahnood, Katherine P Gill, Bernard Yan, Leonid Churilov, Christopher R French, Patricia M Desmond, Malcolm K Horne, Lynette Kiers, Steven Prawer, Stephen M Davis, Anthony N Burkitt, Peter J Mitchell, David B Grayden, Clive N May, Terence J O'Brien

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89 Citations (Scopus)

Abstract

High-fidelity intracranial electrode arrays for recording and stimulating brain activity have facilitated major advances in the treatment of neurological conditions over the past decade. Traditional arrays require direct implantation into the brain via open craniotomy, which can lead to inflammatory tissue responses, necessitating development of minimally invasive approaches that avoid brain trauma. Here we demonstrate the feasibility of chronically recording brain activity from within a vein using a passive stent-electrode recording array (stentrode). We achieved implantation into a superficial cortical vein overlying the motor cortex via catheter angiography and demonstrate neural recordings in freely moving sheep for up to 190 d. Spectral content and bandwidth of vascular electrocorticography were comparable to those of recordings from epidural surface arrays. Venous internal lumen patency was maintained for the duration of implantation. Stentrodes may have wide ranging applications as a neural interface for treatment of a range of neurological conditions.

Original languageEnglish
Pages (from-to)320-327
Number of pages8
JournalNature Biotechnology
Volume34
Issue number3
DOIs
Publication statusPublished - 1 Mar 2016
Externally publishedYes

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