Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity

Thomas J Oxley, Nicholas L Opie, Sam E. John, Gil S Rind, Stephen M Ronayne, Tracey L Wheeler, Jack W. Judy, Alan J McDonald, Anthony Dornom, Timothy J H Lovell, Christopher Steward, David J Garrett, Bradford A Moffat, Elaine H Lui, Nawaf Yassi, Bruce C V Campbell, Yan T Wong, Kate E Fox, Ewan S Nurse, Iwan E Bennett & 19 others Sébastien H Bauquier, Kishan A. Liyanage, Nicole R. Van Der Nagel, Piero Perucca, Arman Ahnood, Katherine P Gill, Bernard Yan, Leonid Churilov, Christopher R French, Patricia M Desmond, Malcolm K Horne, Lynette Kiers, Steven Prawer, Stephen M Davis, Anthony N Burkitt, Peter J Mitchell, David B Grayden, Clive N May, Terence J O'Brien

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Abstract

High-fidelity intracranial electrode arrays for recording and stimulating brain activity have facilitated major advances in the treatment of neurological conditions over the past decade. Traditional arrays require direct implantation into the brain via open craniotomy, which can lead to inflammatory tissue responses, necessitating development of minimally invasive approaches that avoid brain trauma. Here we demonstrate the feasibility of chronically recording brain activity from within a vein using a passive stent-electrode recording array (stentrode). We achieved implantation into a superficial cortical vein overlying the motor cortex via catheter angiography and demonstrate neural recordings in freely moving sheep for up to 190 d. Spectral content and bandwidth of vascular electrocorticography were comparable to those of recordings from epidural surface arrays. Venous internal lumen patency was maintained for the duration of implantation. Stentrodes may have wide ranging applications as a neural interface for treatment of a range of neurological conditions.

Original languageEnglish
Pages (from-to)320-327
Number of pages8
JournalNature Biotechnology
Volume34
Issue number3
DOIs
Publication statusPublished - 1 Mar 2016
Externally publishedYes

Cite this

Oxley, Thomas J ; Opie, Nicholas L ; John, Sam E. ; Rind, Gil S ; Ronayne, Stephen M ; Wheeler, Tracey L ; Judy, Jack W. ; McDonald, Alan J ; Dornom, Anthony ; Lovell, Timothy J H ; Steward, Christopher ; Garrett, David J ; Moffat, Bradford A ; Lui, Elaine H ; Yassi, Nawaf ; Campbell, Bruce C V ; Wong, Yan T ; Fox, Kate E ; Nurse, Ewan S ; Bennett, Iwan E ; Bauquier, Sébastien H ; Liyanage, Kishan A. ; Van Der Nagel, Nicole R. ; Perucca, Piero ; Ahnood, Arman ; Gill, Katherine P ; Yan, Bernard ; Churilov, Leonid ; French, Christopher R ; Desmond, Patricia M ; Horne, Malcolm K ; Kiers, Lynette ; Prawer, Steven ; Davis, Stephen M ; Burkitt, Anthony N ; Mitchell, Peter J ; Grayden, David B ; May, Clive N ; O'Brien, Terence J. / Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity. In: Nature Biotechnology. 2016 ; Vol. 34, No. 3. pp. 320-327.
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abstract = "High-fidelity intracranial electrode arrays for recording and stimulating brain activity have facilitated major advances in the treatment of neurological conditions over the past decade. Traditional arrays require direct implantation into the brain via open craniotomy, which can lead to inflammatory tissue responses, necessitating development of minimally invasive approaches that avoid brain trauma. Here we demonstrate the feasibility of chronically recording brain activity from within a vein using a passive stent-electrode recording array (stentrode). We achieved implantation into a superficial cortical vein overlying the motor cortex via catheter angiography and demonstrate neural recordings in freely moving sheep for up to 190 d. Spectral content and bandwidth of vascular electrocorticography were comparable to those of recordings from epidural surface arrays. Venous internal lumen patency was maintained for the duration of implantation. Stentrodes may have wide ranging applications as a neural interface for treatment of a range of neurological conditions.",
author = "Oxley, {Thomas J} and Opie, {Nicholas L} and John, {Sam E.} and Rind, {Gil S} and Ronayne, {Stephen M} and Wheeler, {Tracey L} and Judy, {Jack W.} and McDonald, {Alan J} and Anthony Dornom and Lovell, {Timothy J H} and Christopher Steward and Garrett, {David J} and Moffat, {Bradford A} and Lui, {Elaine H} and Nawaf Yassi and Campbell, {Bruce C V} and Wong, {Yan T} and Fox, {Kate E} and Nurse, {Ewan S} and Bennett, {Iwan E} and Bauquier, {S{\'e}bastien H} and Liyanage, {Kishan A.} and {Van Der Nagel}, {Nicole R.} and Piero Perucca and Arman Ahnood and Gill, {Katherine P} and Bernard Yan and Leonid Churilov and French, {Christopher R} and Desmond, {Patricia M} and Horne, {Malcolm K} and Lynette Kiers and Steven Prawer and Davis, {Stephen M} and Burkitt, {Anthony N} and Mitchell, {Peter J} and Grayden, {David B} and May, {Clive N} and O'Brien, {Terence J}",
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Oxley, TJ, Opie, NL, John, SE, Rind, GS, Ronayne, SM, Wheeler, TL, Judy, JW, McDonald, AJ, Dornom, A, Lovell, TJH, Steward, C, Garrett, DJ, Moffat, BA, Lui, EH, Yassi, N, Campbell, BCV, Wong, YT, Fox, KE, Nurse, ES, Bennett, IE, Bauquier, SH, Liyanage, KA, Van Der Nagel, NR, Perucca, P, Ahnood, A, Gill, KP, Yan, B, Churilov, L, French, CR, Desmond, PM, Horne, MK, Kiers, L, Prawer, S, Davis, SM, Burkitt, AN, Mitchell, PJ, Grayden, DB, May, CN & O'Brien, TJ 2016, 'Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity', Nature Biotechnology, vol. 34, no. 3, pp. 320-327. https://doi.org/10.1038/nbt.3428

Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity. / Oxley, Thomas J; Opie, Nicholas L; John, Sam E.; Rind, Gil S; Ronayne, Stephen M; Wheeler, Tracey L; Judy, Jack W.; McDonald, Alan J; Dornom, Anthony; Lovell, Timothy J H; Steward, Christopher; Garrett, David J; Moffat, Bradford A; Lui, Elaine H; Yassi, Nawaf; Campbell, Bruce C V; Wong, Yan T; Fox, Kate E; Nurse, Ewan S; Bennett, Iwan E; Bauquier, Sébastien H; Liyanage, Kishan A.; Van Der Nagel, Nicole R.; Perucca, Piero; Ahnood, Arman; Gill, Katherine P; Yan, Bernard; Churilov, Leonid; French, Christopher R; Desmond, Patricia M; Horne, Malcolm K; Kiers, Lynette; Prawer, Steven; Davis, Stephen M; Burkitt, Anthony N; Mitchell, Peter J; Grayden, David B; May, Clive N; O'Brien, Terence J.

In: Nature Biotechnology, Vol. 34, No. 3, 01.03.2016, p. 320-327.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Minimally invasive endovascular stent-electrode array for high-fidelity, chronic recordings of cortical neural activity

AU - Oxley, Thomas J

AU - Opie, Nicholas L

AU - John, Sam E.

AU - Rind, Gil S

AU - Ronayne, Stephen M

AU - Wheeler, Tracey L

AU - Judy, Jack W.

AU - McDonald, Alan J

AU - Dornom, Anthony

AU - Lovell, Timothy J H

AU - Steward, Christopher

AU - Garrett, David J

AU - Moffat, Bradford A

AU - Lui, Elaine H

AU - Yassi, Nawaf

AU - Campbell, Bruce C V

AU - Wong, Yan T

AU - Fox, Kate E

AU - Nurse, Ewan S

AU - Bennett, Iwan E

AU - Bauquier, Sébastien H

AU - Liyanage, Kishan A.

AU - Van Der Nagel, Nicole R.

AU - Perucca, Piero

AU - Ahnood, Arman

AU - Gill, Katherine P

AU - Yan, Bernard

AU - Churilov, Leonid

AU - French, Christopher R

AU - Desmond, Patricia M

AU - Horne, Malcolm K

AU - Kiers, Lynette

AU - Prawer, Steven

AU - Davis, Stephen M

AU - Burkitt, Anthony N

AU - Mitchell, Peter J

AU - Grayden, David B

AU - May, Clive N

AU - O'Brien, Terence J

PY - 2016/3/1

Y1 - 2016/3/1

N2 - High-fidelity intracranial electrode arrays for recording and stimulating brain activity have facilitated major advances in the treatment of neurological conditions over the past decade. Traditional arrays require direct implantation into the brain via open craniotomy, which can lead to inflammatory tissue responses, necessitating development of minimally invasive approaches that avoid brain trauma. Here we demonstrate the feasibility of chronically recording brain activity from within a vein using a passive stent-electrode recording array (stentrode). We achieved implantation into a superficial cortical vein overlying the motor cortex via catheter angiography and demonstrate neural recordings in freely moving sheep for up to 190 d. Spectral content and bandwidth of vascular electrocorticography were comparable to those of recordings from epidural surface arrays. Venous internal lumen patency was maintained for the duration of implantation. Stentrodes may have wide ranging applications as a neural interface for treatment of a range of neurological conditions.

AB - High-fidelity intracranial electrode arrays for recording and stimulating brain activity have facilitated major advances in the treatment of neurological conditions over the past decade. Traditional arrays require direct implantation into the brain via open craniotomy, which can lead to inflammatory tissue responses, necessitating development of minimally invasive approaches that avoid brain trauma. Here we demonstrate the feasibility of chronically recording brain activity from within a vein using a passive stent-electrode recording array (stentrode). We achieved implantation into a superficial cortical vein overlying the motor cortex via catheter angiography and demonstrate neural recordings in freely moving sheep for up to 190 d. Spectral content and bandwidth of vascular electrocorticography were comparable to those of recordings from epidural surface arrays. Venous internal lumen patency was maintained for the duration of implantation. Stentrodes may have wide ranging applications as a neural interface for treatment of a range of neurological conditions.

UR - http://www.scopus.com/inward/record.url?scp=84960857167&partnerID=8YFLogxK

U2 - 10.1038/nbt.3428

DO - 10.1038/nbt.3428

M3 - Article

VL - 34

SP - 320

EP - 327

JO - Nature Biotechnology

JF - Nature Biotechnology

SN - 1087-0156

IS - 3

ER -