Mineralocorticoid receptor signalling in primary aldosteronism

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Primary aldosteronism, or Conn syndrome, is the most common endocrine cause of hypertension. It is associated with a higher risk of cardiovascular, metabolic and renal diseases, as well as a lower quality of life than for hypertension due to other causes. The multi-systemic effects of primary aldosteronism can be attributed to aldosterone-mediated activation of the mineralocorticoid receptor in a range of tissues. In this review, we explore the signalling pathways of the mineralocorticoid receptor, with a shift from the traditional focus on the regulation of renal sodium-potassium exchange to a broader understanding of its role in the modulation of tissue inflammation, fibrosis and remodelling. The appreciation of primary aldosteronism as a multi-system disease with tissue-specific pathophysiology may lead to more vigilant testing and earlier institution of targeted interventions.

Original languageEnglish
Article numbere220249
Number of pages16
JournalJournal of Endocrinology
Issue number1
Publication statusPublished - 1 Sept 2023


  • adrenal cortex
  • aldosterone
  • cortisol
  • mineralocorticoid receptor
  • primary aldosteronism

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