TY - JOUR
T1 - Mineralocorticoid action
T2 - Target tissue specificity is enzyme, not receptor, mediated
AU - Funder, John W.
AU - Pearce, Paul T.
AU - Smith, Robin
AU - Smith, A. Ian
PY - 1988/1/1
Y1 - 1988/1/1
N2 - Mineralocorticoid receptors, both when in tissue extracts and when recombinant-derived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. Such receptors are found in physiological mineralocorticoid target tissues (kidney, parotid, and colon) and in nontarget tissues such as hippocampus and heart. In mineralocorticoid target tissues the receptors are selective for aldosterone in vivo because of the presence of the enzyme 11β-hydroxysteroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs. These analogs cannot bind to mineralcorticoid receptors.
AB - Mineralocorticoid receptors, both when in tissue extracts and when recombinant-derived, have equal affinity for the physiological mineralocorticoid aldosterone and for the glucocorticoids cortisol and corticosterone, which circulate at much higher concentrations than aldosterone. Such receptors are found in physiological mineralocorticoid target tissues (kidney, parotid, and colon) and in nontarget tissues such as hippocampus and heart. In mineralocorticoid target tissues the receptors are selective for aldosterone in vivo because of the presence of the enzyme 11β-hydroxysteroid dehydrogenase, which converts cortisol and corticosterone, but not aldosterone, to their 11-keto analogs. These analogs cannot bind to mineralcorticoid receptors.
UR - http://www.scopus.com/inward/record.url?scp=0023743171&partnerID=8YFLogxK
U2 - 10.1126/science.2845584
DO - 10.1126/science.2845584
M3 - Article
C2 - 2845584
AN - SCOPUS:0023743171
SN - 0036-8075
VL - 242
SP - 583
EP - 585
JO - Science
JF - Science
IS - 4878
ER -