Migrating cells mediate long-range WNT signaling

Research output: Contribution to journalArticleResearchpeer-review

Abstract

In amniotes, it is widely accepted that WNTs secreted by the dorsal neural tube form a concentration gradient that regulates early somite patterning and myotome organization. Here we demonstrate in the chicken embryo that WNT protein is not secreted to act at a distance, but rather loaded onto migrating neural crest cells that deliver it to somites. Inhibiting neural crest migration or ablating their population has a profound impact on the WNT response in somites. Furthermore, we show that a central player in the efficient delivery of WNT to somites is the heparan sulfate proteoglycan GPC4, expressed by neural crest. Together, our data describe a novel mode of signaling whereby WNT proteins hitch a ride on migratory neural crest cells to pattern the somites at a distance from its source.
Original languageEnglish
Pages (from-to)2057 - 2063
Number of pages7
JournalDevelopment
Volume141
Issue number10
DOIs
Publication statusPublished - 2014

Cite this

@article{0fffdbca4cda4cc69914d66060a4582f,
title = "Migrating cells mediate long-range WNT signaling",
abstract = "In amniotes, it is widely accepted that WNTs secreted by the dorsal neural tube form a concentration gradient that regulates early somite patterning and myotome organization. Here we demonstrate in the chicken embryo that WNT protein is not secreted to act at a distance, but rather loaded onto migrating neural crest cells that deliver it to somites. Inhibiting neural crest migration or ablating their population has a profound impact on the WNT response in somites. Furthermore, we show that a central player in the efficient delivery of WNT to somites is the heparan sulfate proteoglycan GPC4, expressed by neural crest. Together, our data describe a novel mode of signaling whereby WNT proteins hitch a ride on migratory neural crest cells to pattern the somites at a distance from its source.",
author = "Olivier Serralbo and Christophe Marcelle",
year = "2014",
doi = "10.1242/dev.107656",
language = "English",
volume = "141",
pages = "2057 -- 2063",
journal = "Development",
issn = "0950-1991",
publisher = "The Company of Biologists Ltd",
number = "10",

}

Migrating cells mediate long-range WNT signaling. / Serralbo, Olivier; Marcelle, Christophe.

In: Development, Vol. 141, No. 10, 2014, p. 2057 - 2063.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Migrating cells mediate long-range WNT signaling

AU - Serralbo, Olivier

AU - Marcelle, Christophe

PY - 2014

Y1 - 2014

N2 - In amniotes, it is widely accepted that WNTs secreted by the dorsal neural tube form a concentration gradient that regulates early somite patterning and myotome organization. Here we demonstrate in the chicken embryo that WNT protein is not secreted to act at a distance, but rather loaded onto migrating neural crest cells that deliver it to somites. Inhibiting neural crest migration or ablating their population has a profound impact on the WNT response in somites. Furthermore, we show that a central player in the efficient delivery of WNT to somites is the heparan sulfate proteoglycan GPC4, expressed by neural crest. Together, our data describe a novel mode of signaling whereby WNT proteins hitch a ride on migratory neural crest cells to pattern the somites at a distance from its source.

AB - In amniotes, it is widely accepted that WNTs secreted by the dorsal neural tube form a concentration gradient that regulates early somite patterning and myotome organization. Here we demonstrate in the chicken embryo that WNT protein is not secreted to act at a distance, but rather loaded onto migrating neural crest cells that deliver it to somites. Inhibiting neural crest migration or ablating their population has a profound impact on the WNT response in somites. Furthermore, we show that a central player in the efficient delivery of WNT to somites is the heparan sulfate proteoglycan GPC4, expressed by neural crest. Together, our data describe a novel mode of signaling whereby WNT proteins hitch a ride on migratory neural crest cells to pattern the somites at a distance from its source.

UR - http://dev.biologists.org/content/141/10/2057.full.pdf

U2 - 10.1242/dev.107656

DO - 10.1242/dev.107656

M3 - Article

VL - 141

SP - 2057

EP - 2063

JO - Development

JF - Development

SN - 0950-1991

IS - 10

ER -