Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2057 - 2063 |
| Number of pages | 7 |
| Journal | Development |
| Volume | 141 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2014 |
Cite this
}
Migrating cells mediate long-range WNT signaling. / Serralbo, Olivier; Marcelle, Christophe.
In: Development, Vol. 141, No. 10, 2014, p. 2057 - 2063.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Migrating cells mediate long-range WNT signaling
AU - Serralbo, Olivier
AU - Marcelle, Christophe
PY - 2014
Y1 - 2014
N2 - In amniotes, it is widely accepted that WNTs secreted by the dorsal neural tube form a concentration gradient that regulates early somite patterning and myotome organization. Here we demonstrate in the chicken embryo that WNT protein is not secreted to act at a distance, but rather loaded onto migrating neural crest cells that deliver it to somites. Inhibiting neural crest migration or ablating their population has a profound impact on the WNT response in somites. Furthermore, we show that a central player in the efficient delivery of WNT to somites is the heparan sulfate proteoglycan GPC4, expressed by neural crest. Together, our data describe a novel mode of signaling whereby WNT proteins hitch a ride on migratory neural crest cells to pattern the somites at a distance from its source.
AB - In amniotes, it is widely accepted that WNTs secreted by the dorsal neural tube form a concentration gradient that regulates early somite patterning and myotome organization. Here we demonstrate in the chicken embryo that WNT protein is not secreted to act at a distance, but rather loaded onto migrating neural crest cells that deliver it to somites. Inhibiting neural crest migration or ablating their population has a profound impact on the WNT response in somites. Furthermore, we show that a central player in the efficient delivery of WNT to somites is the heparan sulfate proteoglycan GPC4, expressed by neural crest. Together, our data describe a novel mode of signaling whereby WNT proteins hitch a ride on migratory neural crest cells to pattern the somites at a distance from its source.
UR - http://dev.biologists.org/content/141/10/2057.full.pdf
U2 - 10.1242/dev.107656
DO - 10.1242/dev.107656
M3 - Article
VL - 141
SP - 2057
EP - 2063
JO - Development
JF - Development
SN - 0950-1991
IS - 10
ER -