Migralepsy: A call for a revision of the definition

Grazia Sances, Elena Guaschino, Piero Perucca, Marta Allena, Natascia Ghiotto, Raffaele Manni

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)


Migralepsy is an ill-defined nosologic entity, with only a few cases described in the literature. In the 2004 International Classification for Headache Disorders (ICHD-II), the International Headache Society proposed that the following diagnostic criteria should be met: (1) migraine fulfilling criteria for 1.2 Migraine with aura (MA) and (2) a seizure fulfilling diagnostic criteria for one type of epileptic attack occurs during or within 1 h after a migraine aura. Herein, by presenting a case with symptoms suggestive of migralepsy and by reviewing all previous cases described in the literature, we discuss the challenges of differentiating this condition from epileptic seizures, as well as the inaccuracy of the current ICHD-II definition.

Original languageEnglish
Pages (from-to)2487-2496
Number of pages10
Issue number11
Publication statusPublished - Nov 2009
Externally publishedYes


  • Epilepsy
  • Migraine
  • Migralepsy

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