Midline brain abnormalities in established bipolar affective disorder

Tsutomu Takahashi, Gin Singh Malhi, Stephen J Wood, Murat Yucel, Mark Walterfang, Kazue Nakamura, Michio Suzuki, Christos Pantelis

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

Morphologic changes of cortico-limbic regions have been reported in bipolar disorder, but it remains unclear whether midline brain abnormalities relevant to cortico-limbic connectivity are also present. Methods: We used magnetic resonance imaging to investigate the size of the adhesio interthalamica (AI) and cavum septi pellucidi (CSP), as well as third ventricular volume, in 26 patients with bipolar I disorder and 24 matched controls. Results: CSP length and prevalence of a large CSP did not differ between the groups, but bipolar patients had significantly shorter AI and larger third ventricles compared to controls. Limitations: A comprehensive investigation of medication effects was not possible due to incomplete medication data. Conclusions: These findings implicate a role for the AI and connected brain regions in the neurobiology of bipolar disorder.
Original languageEnglish
Pages (from-to)301 - 305
Number of pages5
JournalJournal of Affective Disorders
Volume122
Issue number3
DOIs
Publication statusPublished - 2010
Externally publishedYes

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