Abstract
Morphologic changes of cortico-limbic regions have been reported in bipolar disorder, but it remains unclear whether midline brain abnormalities relevant to cortico-limbic connectivity are also present. Methods: We used magnetic resonance imaging to investigate the size of the adhesio interthalamica (AI) and cavum septi pellucidi (CSP), as well as third ventricular volume, in 26 patients with bipolar I disorder and 24 matched controls. Results: CSP length and prevalence of a large CSP did not differ between the groups, but bipolar patients had significantly shorter AI and larger third ventricles compared to controls. Limitations: A comprehensive investigation of medication effects was not possible due to incomplete medication data. Conclusions: These findings implicate a role for the AI and connected brain regions in the neurobiology of bipolar disorder.
Original language | English |
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Pages (from-to) | 301 - 305 |
Number of pages | 5 |
Journal | Journal of Affective Disorders |
Volume | 122 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2010 |
Externally published | Yes |