Microwave heating of poly(N-isopropylacrylamide)-conjugated gold nanoparticles for temperature-controlled display of concanavalin A

Roshan B. Vasani, Nayana Janardanan, Beatriz Prieto-Simón, Anna Cifuentes-Rius, Siobhan J. Bradley, Eli Moore, Tobias Kraus, Nicolas H. Voelcker

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16 Citations (Scopus)


We demonstrate microwave-induced heating of gold nanoparticles and nanorods. An appreciably higher and concentration-dependent microwave-induced heating rate was observed with aqueous dispersions of the nanomaterials as opposed to pure water and other controls. Grafted with the thermoresponsive polymer poly(N-isopropylacrylamide), these gold nanomaterials react to microwave-induced heating with a conformational change in the polymer shell, leading to particle aggregation. We subsequently covalently immobilize concanavalin A (Con A) on the thermoresponsive gold nanoparticles. Con A is a bioreceptor commonly used in bacterial sensors because of its affinity for carbohydrates on bacterial cell surfaces. The microwave-induced thermal transitions of the polymer reversibly switch on and off the display of Con A on the particle surface and hence the interactions of the nanomaterials with carbohydrate-functionalized surfaces. This effect was determined using linear sweep voltammetry on a methyl-α-d-mannopyranoside-functionalized electrode.

Original languageEnglish
Pages (from-to)27755-27764
Number of pages10
JournalACS Applied Materials & Interfaces
Issue number50
Publication statusPublished - 23 Dec 2015
Externally publishedYes


  • concanavalin A
  • controlled display
  • gold nanoparticles
  • microwave heating
  • poly(N-isopropylacrylamide)

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