Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-a,a-disubstituted amino acids

Julia Cianci; Jonathan Bayldon Baell; Andrew J Harvey

doi:10.1016/j.tetlet.2007.06.109

Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-a,a-disubstituted amino acids

Julia Cianci, Jonathan Bayldon Baell, Andrew J Harvey

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

Incorporation of the extremely hindered amino acid N-benzylaminoisobutyric acid into dipeptides under microwave irradiation with commercial zinc dust is described. A comparative survey of various methodologies for hindered peptide couplings was undertaken. The optimised coupling conditions were free from racemisation and applicable to other hindered amino acids

Original language	English
Pages (from-to)	5973 - 5975
Number of pages	3
Journal	Tetrahedron Letters
Volume	48
Issue number	34
DOIs	https://doi.org/10.1016/j.tetlet.2007.06.109
Publication status	Published - 2007
Externally published	Yes

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10.1016/j.tetlet.2007.06.109

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@article{ab38bad38c214a10bdec9a51f833ca28,

title = "Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-a,a-disubstituted amino acids",

abstract = "Incorporation of the extremely hindered amino acid N-benzylaminoisobutyric acid into dipeptides under microwave irradiation with commercial zinc dust is described. A comparative survey of various methodologies for hindered peptide couplings was undertaken. The optimised coupling conditions were free from racemisation and applicable to other hindered amino acids",

author = "Julia Cianci and Baell, {Jonathan Bayldon} and Harvey, {Andrew J}",

year = "2007",

doi = "10.1016/j.tetlet.2007.06.109",

language = "English",

volume = "48",

pages = "5973 -- 5975",

journal = "Tetrahedron Letters",

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number = "34",

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TY - JOUR

T1 - Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-a,a-disubstituted amino acids

AU - Cianci, Julia

AU - Baell, Jonathan Bayldon

AU - Harvey, Andrew J

PY - 2007

Y1 - 2007

N2 - Incorporation of the extremely hindered amino acid N-benzylaminoisobutyric acid into dipeptides under microwave irradiation with commercial zinc dust is described. A comparative survey of various methodologies for hindered peptide couplings was undertaken. The optimised coupling conditions were free from racemisation and applicable to other hindered amino acids

AB - Incorporation of the extremely hindered amino acid N-benzylaminoisobutyric acid into dipeptides under microwave irradiation with commercial zinc dust is described. A comparative survey of various methodologies for hindered peptide couplings was undertaken. The optimised coupling conditions were free from racemisation and applicable to other hindered amino acids

UR - http://www.sciencedirect.com/science/article/pii/S0040403907012269

U2 - 10.1016/j.tetlet.2007.06.109

DO - 10.1016/j.tetlet.2007.06.109

M3 - Article

VL - 48

SP - 5973

EP - 5975

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 34

ER -

Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-a,a-disubstituted amino acids

Abstract

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