Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-a,a-disubstituted amino acids

Julia Cianci, Jonathan Bayldon Baell, Andrew J Harvey

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Abstract

Incorporation of the extremely hindered amino acid N-benzylaminoisobutyric acid into dipeptides under microwave irradiation with commercial zinc dust is described. A comparative survey of various methodologies for hindered peptide couplings was undertaken. The optimised coupling conditions were free from racemisation and applicable to other hindered amino acids
Original languageEnglish
Pages (from-to)5973 - 5975
Number of pages3
JournalTetrahedron Letters
Volume48
Issue number34
DOIs
Publication statusPublished - 2007
Externally publishedYes

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