Abstract
Shorter reaction times, higher product yields and enhanced selectivity are some of the outstanding advantages over conventional methods that the microwave-assisted organic synthesis possesses, which makes this methods develop into a significant mainstream both in industrial usages and academic researches. Microwave-assisted organic synthesis as a new protocol for green chemistry showcases the application of microwave heating in a number of areas of preparative chemistry as well as in the biosciences. Many name reactions can be performed by microwave-assisted, including the Diels-Alder reaction, the Witting reaction, the Heck reaction and the Mannich reaction. Meanwhile, α-diazoester was already a mature science 20 years ago, some areas that continue to attract the most attention are preparation of diazoester substrates, such as the Wolff rearrangement, C-H insertion, N-H insertion, Si-H insertion and so on. Therefore, it is necessary to develop a green and efficient method for the preparation of α-diazoester. Herein a new method of microwave-assisted synthesis of α-diazoesters compounds from 2-phenylacetates and tosyl azide in 30 min is described. The protocol provides a quick, efficient and green approach to various α-diazoesters compounds with up to 90% isolated yields and a broad range of functional groups.
Translated title of the contribution | Microwave-Assisted Synthesis of α-Diazoesters |
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Original language | Chinese |
Pages (from-to) | 544-549 |
Number of pages | 6 |
Journal | Chinese Journal of Organic Chemistry |
Volume | 39 |
Issue number | 2 |
DOIs | |
Publication status | Published - 25 Feb 2019 |
Externally published | Yes |
Keywords
- Green chemistry
- Microwave-assisted
- α-diazoester