微波辅助α-重氮酯类化合物的快速合成

Translated title of the contribution: Microwave-Assisted Synthesis of α-Diazoesters

Xiangyan Yi, Zhipeng Zhang, He Huang, Jonathan B. Baell, Yang Yu, Fei Huang

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Shorter reaction times, higher product yields and enhanced selectivity are some of the outstanding advantages over conventional methods that the microwave-assisted organic synthesis possesses, which makes this methods develop into a significant mainstream both in industrial usages and academic researches. Microwave-assisted organic synthesis as a new protocol for green chemistry showcases the application of microwave heating in a number of areas of preparative chemistry as well as in the biosciences. Many name reactions can be performed by microwave-assisted, including the Diels-Alder reaction, the Witting reaction, the Heck reaction and the Mannich reaction. Meanwhile, α-diazoester was already a mature science 20 years ago, some areas that continue to attract the most attention are preparation of diazoester substrates, such as the Wolff rearrangement, C-H insertion, N-H insertion, Si-H insertion and so on. Therefore, it is necessary to develop a green and efficient method for the preparation of α-diazoester. Herein a new method of microwave-assisted synthesis of α-diazoesters compounds from 2-phenylacetates and tosyl azide in 30 min is described. The protocol provides a quick, efficient and green approach to various α-diazoesters compounds with up to 90% isolated yields and a broad range of functional groups.

Translated title of the contributionMicrowave-Assisted Synthesis of α-Diazoesters
Original languageChinese
Pages (from-to)544-549
Number of pages6
JournalChinese Journal of Organic Chemistry
Volume39
Issue number2
DOIs
Publication statusPublished - 25 Feb 2019
Externally publishedYes

Keywords

  • Green chemistry
  • Microwave-assisted
  • α-diazoester

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