Microstamp patterning of protein arrays

Mahyar Nasabi, Arnan Mitchell, Kourosh Kalantar-Zadeh, Warwick S. Nesbitt

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1 Citation (Scopus)

Abstract

Pathological thrombus formation is initiated by the interaction of blood platelets to immobilized proteins at the vessel wall. Platelet surface adhesion leads to biochemical activation and structural reorganization resulting in spreading of the platelet across the adhesive surface. Extensive studies have been carried out to examine platelet spreading responses on continuous substrates but little is known about the impact of protein surface distribution on platelet function. This paper describes the development of a micro-contact printing technique to establish defined 2-dimensional arrays of the thrombogenic protein fibrinogen at the surface of glass substrates, with the aim of investigating the impact of protein surface distribution on platelet biochemical signaling events associated with the adhesion/spreading process.

Original languageEnglish
Title of host publicationProceedings of the 2008 International Conference on Nanoscience and Nanotechnology, ICONN 2008
Pages117-120
Number of pages4
DOIs
Publication statusPublished - 24 Nov 2008
EventInternational Conference on Nanoscience and Nanotechnology (ICONN) - Melbourne Convention Centre, Melbourne Vic, Australia
Duration: 25 Feb 200829 Feb 2008

Conference

ConferenceInternational Conference on Nanoscience and Nanotechnology (ICONN)
Abbreviated titleICONN 2008
CountryAustralia
CityMelbourne Vic
Period25/02/0829/02/08

Keywords

  • Fibrinogen
  • Microstamp
  • PDMS
  • Platelet

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