MicroRNAs: The fine-tuners of Toll-like receptor signalling

Luke O'Neill, Frederick Sheedy, Claire McCoy

Research output: Contribution to journalArticleResearchpeer-review

600 Citations (Scopus)


Toll-like receptor (TLR) signalling must be tightly regulated to avoid excessive inflammation and to allow for tissue repair and the return to homeostasis after infection and tissue injury. MicroRNAs (miRNAs) have emerged as important controllers of TLR signalling. Several miRNAs are induced by TLR activation in innate immune cells and these and other miRNAs target the 3 untranslated regions of mRNAs encoding components of the TLR signalling system. miRNAs are also proving to be an important link between the innate and adaptive immune systems, and their dysregulation might have a role in the pathogenesis of inflammatory diseases.
Original languageEnglish
Pages (from-to)163 - 175
Number of pages13
JournalNature Reviews Immunology
Issue number3
Publication statusPublished - 2011

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