MicroRNAs in common diseases and potential therapeutic applications

Louis Tsai, Di Yu

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Abstract

1. Evidence gathered in recent years has revealed microRNAs (miRNAs) fine-tune gene expression and play an important role in various cellular processes, including cell growth, differentiation, proliferation and apoptosis. 2. The present review summarizes current knowledge of miRNA pathways in the pathogenesis of cancer, cardiac diseases, neurodegenerative diseases, diabetes, autoimmune/inflammatory diseases and infection. 3. There is considerable potential to target miRNAs as a novel approach in the treatment of human diseases. Currently, miRNA-based therapies are being examined in both animal models and human clinical trials.
Original languageEnglish
Pages (from-to)102 - 107
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Volume37
Issue number1
DOIs
Publication statusPublished - 2010
Externally publishedYes

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