MicroRNAs in cerebral ischemia

Kai Ying Lim, Jia Hui Chua, Jun Rong Tan, Priyadharshni Swaminathan, Sugunavathi Sepramaniam, Arunmozhiarasi Armugam, Peter Tsun Hon Wong, Kandiah Jeyaseelan

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29 Citations (Scopus)

Abstract

Pathogenesis of cerebral ischemia has so far been described in the context of proteins and the pathways that they regulate. The discovery of biomarkers has also been focussed mainly on proteins and to some extent on the mRNAs that encode them. The knowledge on the role of microRNAs in understanding the pathogenesis of cerebral ischemia is still at its infancy. In this study, using rat models subjected to middle cerebral artery occlusion, we have profiled the microRNAs at different reperfusion times (0 to 48 h) to understand the progression of cerebral ischemia. We have also attempted to correlate the expression of microRNAs to treatment with an NMDA antagonist (MK801) and to protein expression with the hope of demonstrating the potential use of microRNAs as early biomarkers of stroke.

Original languageEnglish
Pages (from-to)287-303
Number of pages17
JournalTranslational Stroke Research
Volume1
Issue number4
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Keywords

  • Acute phase
  • Biomarkers
  • Cerebral ischemia
  • Gene
  • MCAo
  • MicroRNA

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