TY - JOUR
T1 - MicroRNAs in cerebral ischemia
AU - Lim, Kai Ying
AU - Chua, Jia Hui
AU - Tan, Jun Rong
AU - Swaminathan, Priyadharshni
AU - Sepramaniam, Sugunavathi
AU - Armugam, Arunmozhiarasi
AU - Wong, Peter Tsun Hon
AU - Jeyaseelan, Kandiah
PY - 2010/12
Y1 - 2010/12
N2 - Pathogenesis of cerebral ischemia has so far been described in the context of proteins and the pathways that they regulate. The discovery of biomarkers has also been focussed mainly on proteins and to some extent on the mRNAs that encode them. The knowledge on the role of microRNAs in understanding the pathogenesis of cerebral ischemia is still at its infancy. In this study, using rat models subjected to middle cerebral artery occlusion, we have profiled the microRNAs at different reperfusion times (0 to 48 h) to understand the progression of cerebral ischemia. We have also attempted to correlate the expression of microRNAs to treatment with an NMDA antagonist (MK801) and to protein expression with the hope of demonstrating the potential use of microRNAs as early biomarkers of stroke.
AB - Pathogenesis of cerebral ischemia has so far been described in the context of proteins and the pathways that they regulate. The discovery of biomarkers has also been focussed mainly on proteins and to some extent on the mRNAs that encode them. The knowledge on the role of microRNAs in understanding the pathogenesis of cerebral ischemia is still at its infancy. In this study, using rat models subjected to middle cerebral artery occlusion, we have profiled the microRNAs at different reperfusion times (0 to 48 h) to understand the progression of cerebral ischemia. We have also attempted to correlate the expression of microRNAs to treatment with an NMDA antagonist (MK801) and to protein expression with the hope of demonstrating the potential use of microRNAs as early biomarkers of stroke.
KW - Acute phase
KW - Biomarkers
KW - Cerebral ischemia
KW - Gene
KW - MCAo
KW - MicroRNA
UR - http://www.scopus.com/inward/record.url?scp=78649475655&partnerID=8YFLogxK
U2 - 10.1007/s12975-010-0035-3
DO - 10.1007/s12975-010-0035-3
M3 - Article
AN - SCOPUS:78649475655
VL - 1
SP - 287
EP - 303
JO - Translational Stroke Research
JF - Translational Stroke Research
SN - 1868-4483
IS - 4
ER -