microRNA Decay: Refining microRNA Regulatory Activity

Genevieve Pepin, Michael P. Gantier

Research output: Contribution to journalReview ArticleOtherpeer-review

8 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are short 19-25 nucleotide RNA molecules that impact on most biological processes by regulating the efficiency of messenger RNA (mRNA) translation. To date, most research activities have been focused on the control of miRNA expression and its functional consequences. Nonetheless, much remains unknown about the mechanisms affecting the level of specific miRNAs in the cell, a critical feature impacting their regulatory activity. This review focuses on the factors that regulate the abundance of miRNAs, including synthesis, post-transcriptional modifications, nucleases, target binding, and secretion.

Original languageEnglish
Pages (from-to)167-174
Number of pages8
JournalMicrorna
Volume5
Issue number3
DOIs
Publication statusPublished - 2016

Keywords

  • cleavage
  • degradation
  • exosome
  • microRNA
  • RNase
  • target mRNA

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