Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 167-174 |
| Number of pages | 8 |
| Journal | Microrna |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2016 |
Keywords
- cleavage
- degradation
- exosome
- microRNA
- RNase
- target mRNA
Cite this
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microRNA Decay: Refining microRNA Regulatory Activity. / Pepin, Genevieve; Gantier, Michael Paul Marie.
In: Microrna, Vol. 5, No. 3, 2016, p. 167-174.Research output: Contribution to journal › Review Article › Other › peer-review
TY - JOUR
T1 - microRNA Decay: Refining microRNA Regulatory Activity
AU - Pepin, Genevieve
AU - Gantier, Michael Paul Marie
PY - 2016
Y1 - 2016
N2 - MicroRNAs (miRNAs) are short 19-25 nucleotide RNA molecules that impact on most biological processes by regulating the efficiency of messenger RNA (mRNA) translation. To date, most research activities have been focused on the control of miRNA expression and its functional consequences. Nonetheless, much remains unknown about the mechanisms affecting the level of specific miRNAs in the cell, a critical feature impacting their regulatory activity. This review focuses on the factors that regulate the abundance of miRNAs, including synthesis, post-transcriptional modifications, nucleases, target binding, and secretion.
AB - MicroRNAs (miRNAs) are short 19-25 nucleotide RNA molecules that impact on most biological processes by regulating the efficiency of messenger RNA (mRNA) translation. To date, most research activities have been focused on the control of miRNA expression and its functional consequences. Nonetheless, much remains unknown about the mechanisms affecting the level of specific miRNAs in the cell, a critical feature impacting their regulatory activity. This review focuses on the factors that regulate the abundance of miRNAs, including synthesis, post-transcriptional modifications, nucleases, target binding, and secretion.
KW - cleavage
KW - degradation
KW - exosome
KW - microRNA
KW - RNase
KW - target mRNA
U2 - 10.2174/221153660566616102716 5915
DO - 10.2174/221153660566616102716 5915
M3 - Review Article
VL - 5
SP - 167
EP - 174
JO - Microrna
JF - Microrna
SN - 2211-5374
IS - 3
ER -