Microparticles: major transport vehicles for distinct microRNAs in circulation

Philipp Diehl; Alba Fricke; Laura Sander; Johannes Stamm; Nicole Bassler; Nay Htun; Mark Ziemann; Thomas Helbing; Assam El-Osta; Jeremy B Jowett; Karlheinz Peter

doi:10.1093/cvr/cvs007

Microparticles: major transport vehicles for distinct microRNAs in circulation

Philipp Diehl
, Alba Fricke
, Laura Sander
, Johannes Stamm
, Nicole Bassler
, Nay Htun
, Mark Ziemann
, Thomas Helbing
, Assam El-Osta
, Jeremy B Jowett
, Karlheinz Peter

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

444 Citations (Scopus)

Abstract

Circulating microRNAs (miRNAs) have attracted major interest as biomarkers for cardiovascular diseases. Since RNases are abundant in circulating blood, there needs to be a mechanism protecting miRNAs from degradation. We hypothesized that microparticles (MP) represent protective transport vehicles for miRNAs and that these are specifically packaged by their maternal cells.

Original language	English
Pages (from-to)	633-644
Number of pages	12
Journal	Cardiovascular Research
Volume	93
Issue number	4
DOIs	https://doi.org/10.1093/cvr/cvs007
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

MicroRNA
Microparticles
Vascular inflammation

Access to Document

10.1093/cvr/cvs007

Cite this

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title = "Microparticles: major transport vehicles for distinct microRNAs in circulation",

abstract = "Circulating microRNAs (miRNAs) have attracted major interest as biomarkers for cardiovascular diseases. Since RNases are abundant in circulating blood, there needs to be a mechanism protecting miRNAs from degradation. We hypothesized that microparticles (MP) represent protective transport vehicles for miRNAs and that these are specifically packaged by their maternal cells.",

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author = "Philipp Diehl and Alba Fricke and Laura Sander and Johannes Stamm and Nicole Bassler and Nay Htun and Mark Ziemann and Thomas Helbing and Assam El-Osta and Jowett, \{Jeremy B\} and Karlheinz Peter",

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AU - Diehl, Philipp

AU - Fricke, Alba

AU - Sander, Laura

AU - Stamm, Johannes

AU - Bassler, Nicole

AU - Htun, Nay

AU - Ziemann, Mark

AU - Helbing, Thomas

AU - El-Osta, Assam

AU - Jowett, Jeremy B

AU - Peter, Karlheinz

PY - 2012

Y1 - 2012

N2 - Circulating microRNAs (miRNAs) have attracted major interest as biomarkers for cardiovascular diseases. Since RNases are abundant in circulating blood, there needs to be a mechanism protecting miRNAs from degradation. We hypothesized that microparticles (MP) represent protective transport vehicles for miRNAs and that these are specifically packaged by their maternal cells.

AB - Circulating microRNAs (miRNAs) have attracted major interest as biomarkers for cardiovascular diseases. Since RNases are abundant in circulating blood, there needs to be a mechanism protecting miRNAs from degradation. We hypothesized that microparticles (MP) represent protective transport vehicles for miRNAs and that these are specifically packaged by their maternal cells.

KW - MicroRNA

KW - Microparticles

KW - Vascular inflammation

UR - http://cardiovascres.oxfordjournals.org/content/93/4/633.full.pdf

U2 - 10.1093/cvr/cvs007

DO - 10.1093/cvr/cvs007

M3 - Article

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VL - 93

SP - 633

EP - 644

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 4

ER -

Microparticles: major transport vehicles for distinct microRNAs in circulation

Abstract

UN SDGs

Keywords

Access to Document

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Cite this