TY - CHAP
T1 - Microglial Function in MS Pathology
AU - Kilpatrick, Trevor
AU - Jokubaitis, Vilija Genevieve
N1 - Funding Information:
This work has been supported by Erasmus Research Institute of Management of the Erasmus University Rotterdam, and the SMARTA theme of the Swedish National Institute for Working Life. We are thankful for the workshop participants who included: Mark Boocock, Tony Vitalis, Stefano Marzani, Arne Bilberg, Anabella Simoes, Pedro Ferreira, Damian Graham, Canan Ceylan, Ole Broberg, Roberto Montanari, Enda Fallon, and Reem Aekadeem.
Publisher Copyright:
© Springer Science+Business Media New York 2013.
PY - 2013
Y1 - 2013
N2 - In the quiescent state, ramified microglia are responsible for routine immune surveillance within the central nervous system. In response to injury or insult, microglia become activated and undergo morphological change to a hyper-ramified, activated or amoeboid morphology (Streit et al., Prog Neurobiol 57(6):563–581, 1999; see Fig. 3.1). It has long been held that microglial activation is deleterious during MS lesion evolution. However, more recently, beneficial roles have also been ascribed to microglia during MS pathogenesis with evidence gleaned predominantly from animal models. In this chapter, microglial function in the context of MS will be discussed with evidence drawn from both human pathology and animal models. Microglial phagocytic activity, remodelling, inflammation, immunomodulation and repair will be examined and the molecular mechanisms that are posited to underpin these disparate roles critiqued.
AB - In the quiescent state, ramified microglia are responsible for routine immune surveillance within the central nervous system. In response to injury or insult, microglia become activated and undergo morphological change to a hyper-ramified, activated or amoeboid morphology (Streit et al., Prog Neurobiol 57(6):563–581, 1999; see Fig. 3.1). It has long been held that microglial activation is deleterious during MS lesion evolution. However, more recently, beneficial roles have also been ascribed to microglia during MS pathogenesis with evidence gleaned predominantly from animal models. In this chapter, microglial function in the context of MS will be discussed with evidence drawn from both human pathology and animal models. Microglial phagocytic activity, remodelling, inflammation, immunomodulation and repair will be examined and the molecular mechanisms that are posited to underpin these disparate roles critiqued.
KW - Central Nervous System Parenchyma
KW - Experimental Autoimmune Encephalomyelitis
KW - Leukaemia Inhibitory Factor
KW - Microglial Activation
KW - Myelin Debris
UR - http://www.scopus.com/inward/record.url?scp=84937769033&partnerID=8YFLogxK
U2 - 10.1007/978-1-4614-2218-1_3
DO - 10.1007/978-1-4614-2218-1_3
M3 - Chapter (Book)
AN - SCOPUS:84937769033
SN - 9781461422174
SP - 47
EP - 70
BT - Myelin Repair and Neuroprotection in Multiple Sclerosis
A2 - Duncan, Ian D.
A2 - Franklin, Robin J.M.
PB - Springer
CY - New York
ER -